Naslov
Hair tungsten (wolfram) is increased in human depression

Autori
Prejac, Juraj ; Badzek, Saša ; Višnjević, Vjeran ; Mimica, Ninoslav ; Skalny, A. Andrei ; Momčilović, Berislav

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Abstracts of the 14th International Symposium on Trace Elements in Man and Animals - Exploring Trace Elements: Science, Innovation, & Application / Xingen, Lei - Lahti : Chinese Nutrition Society, 2011, 253-253

Skup
14th International Symposium on Trace Elements in Man and Animals (TEMA 14)

Mjesto i datum
Enshi, Kina, 19.09.2011. - 24.09.2011

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
tungsten; hair and blood; depression

Sažetak
Tungsten (W) is a non-essential element of a low order of toxictiy. The tungsten (W) ion antagonises the normal metabolic action of the molybate ion, and therefore can inhibit molybdate- dependent enzymes. We studied the distribution of tungsten (W) in the hair and whole blood of occupationally non-exposed depressed (n=48 ; 15 men, 33 women) and control (n=48 ; 28 men, 25 women) subjects. Depression was diagnosed by the certified psychiatrist following the DSM-IV criteria. The study was conducted following the declaration of Helsinki on the ethics of the human subject research. Tungsten (W) analysis was performed by ICP-MS at the CBM, Moscow, Russia, an ISO certified analytical laboratory. International certified standards for hair and whole blood analysis were used for the control. There were no difference in tungsten (W) hair and whole blood concentration between men and women. Median tungsten (W) concentration was increased in the hair of depressed subjects (depressed 0.020 jig/gE"1, control 0.007 |ig/gE_1), and median concentration of tungsten (W) in the blood was also increased in the depressed subjects (depression 0.0031 jig/gE"1, control 0.000385 jug/gE"1). The difference was statistically significant by the chi-square test (p < 0.01 for the hair and p < 0.05 for the whole blood). Hair appears to be a more sensitive indicator tissue for assessing tungsten (W) metabolism than whole blood. The reason for observed difference of greater tungsten (W) accumulation in the hair and whole blood of depressed than in the normal subjects remains to be elucidated.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti

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