Pregled bibliografske jedinice broj: 73645
The role of programmed cell death in Werdnig-Hoffmann disease
The role of programmed cell death in Werdnig-Hoffmann disease // The First Summer School of Croatian Institute for Brain Research 'Brain Development, Injury and Repair', Zagreb, 5-7. VII 1999.
Zagreb, 1999. (pozvano predavanje, domaća recenzija, sažetak, znanstveni)
CROSBI ID: 73645 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
The role of programmed cell death in Werdnig-Hoffmann disease
Autori
Šimić, Goran
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni
Izvornik
The First Summer School of Croatian Institute for Brain Research 'Brain Development, Injury and Repair', Zagreb, 5-7. VII 1999.
/ - Zagreb, 1999
Skup
The First Summer School of Croatian Institute for Brain Research 'Brain Development, Injury and Repair', Zagreb, 5-7. VII 1999.
Mjesto i datum
Zagreb, Hrvatska, 05.07.1999. - 07.07.1999
Vrsta sudjelovanja
Pozvano predavanje
Vrsta recenzije
Domaća recenzija
Ključne riječi
spinal muscular atrophy; pathogenesis; apoptosis
Sažetak
The development of the vertebrate nervous system is characterized by an initial overproduction of neurons in many regions followed by large-scale elimination. It is esimated that, immediately following the arrival of their axons in muscle cells, about 40-70% of the embryonic motor neurons in the spinal cord undergo naturally occurring programmed cell death during the midgestational period (15-25 weeks of gestation in the human fetus). The hypothesis that spinal muscular atrophies, particularly Werdnig-Hoffmann disease or SMA type-1, is based on an inappropriate persistence of normally occurring apoptosis is presented and discussed with respect to recent genetic and neuropathological results from our and other laboratories.
Izvorni jezik
Engleski
Znanstvena područja
Kliničke medicinske znanosti
