Naslov
Neonatal giant cell hepatitis. An unusual cause of new-born child death. Report of two cases

Autori
Mrčela, Milanka ; Dmitrović, Branko

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, ostalo

Izvornik
Virchows Archiv / - Heidelberg : Springer, 2007, 255-255

Skup
21st European Congress of Pathology

Mjesto i datum
Istanbul, Turska, 08.09.2007. - 13.09.2007

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
neonatal giant cell hepatitis

Sažetak
Neonatal giant cell hepatitis is a very rare condition in a clinical praxis. It is characterized by syncytial cell hepatocytes. Both children with neonatal giant cell hepatitis were born in the same family in a two year interval and both died in the first 24 hour period. In the first case the female child's autopsy finding showed haemorrhagic diathesis: intraalveolar, kidney and ventricular mucosae bleeding. In the second case the male new-born child's autopsy finding showed petechial cutaneous bleeding of the head, trunck and extremities, fetal hydrops and ascites. Both cases share the same histological findings in the liver. Severe disorder of the liver parenchima with syncytial giant cell hepatocytes contained yellow pigment which react with Berlin blue. As hemosiderin deposites were found in the multinucleated transformed hepatocytes, we concluded that the metabolic disorder in transportation and storage of iron is in the background of both cases so that hepatocellular damage caused fatal haemorrhagic disorder.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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