Pregled bibliografske jedinice broj: 736298
Brain washout of Tc-99m-L, L-ethyl cysteinate dimer (ECD) in normal volunteers
Brain washout of Tc-99m-L, L-ethyl cysteinate dimer (ECD) in normal volunteers // Nuklearmedizin, 25 (1989), 292-295 (međunarodna recenzija, članak, znanstveni)
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Naslov
Brain washout of Tc-99m-L, L-ethyl cysteinate dimer (ECD) in normal volunteers
Autori
Franceschi, Maja ; Picard, Michel ; Zimmerman, Robert E. ; Kronauge, Jim F. ; Jones, Alun G. ; Holman, B. Leonard
Izvornik
Nuklearmedizin (0029-5566) 25
(1989);
292-295
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
brain washout; ECD; SPECT
Sažetak
Tc-99m ECD, a new derivative of diamine dithiol (DADT) family, has been developed recently. This lipophilic neutral Tc-99m complex in the L-L stereoisomeric form crosses the blood-brain barrier and reacts with a specific esterase enzyme which hydrolyses the two ester groups, resulting in Tc-99m ECD retention in the brain (Walovitch 1988). Tc-99m ECD demonstrated high initial cerebral uptake and slow clearance in non-human primates, characteristics suitable for SPECT imaging. Using planar and SPECT techniques, we determined brain washout characteristics of Tc-99m ECD in normal humans.
Izvorni jezik
Engleski
Znanstvena područja
Kliničke medicinske znanosti
Citiraj ovu publikaciju:
Časopis indeksira:
- Scopus
- MEDLINE
