Naslov
Evidence that Ginkgo biloba extract does not inhibit MAO A and B in living human brain

Autori
Fowler, Joanna S. ; Wang, Gene-Jack ; Volkow, Nora D. ; Logan, Jean ; Franceschi, Dinko ; Franceschi, Maja ; MacGregor, Robert ; Shea, Colleen ; Garza, Victor ; Liu, Ning ; Ding, Yu-Shin

Izvornik
Life sciences (0024-3205) 66 (2000), 9; 141-146

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Egb 761 ; Ginkgo biloba ; MAO A ; MAO B ; PET

Sažetak
Extracts of Ginkgo biloba have been reported to reversibly inhibit both monoamine oxidase (MAO) A and B in rat brain in vitro leading to speculation that MAO inhibition may contribute to some of its central nervous system effects. Here we have used positron emission tomography (PET) to measure the effects of Ginkgo biloba on human brain MAO A and B in 10 subjects treated for 1 month with 120 mg/day of the Ginkgo biloba extract EGb 761, using [ 11C]clorgyline and [ 11C]L-deprenyl-D2 to measure MAO A and B respectively. A three-compartment model was used to calculate the plasma to brain transfer constant K 1 which is related to blood flow, and λk 3, a model term which is a function of the concentration of catalytically active MAO molecules. Ginkgo biloba administration did not produce significant changes in brain MAO A or MAO B suggesting that mechanisms other than MAO inhibition need to be considered as mediating some of its CNS effects.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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