Naslov
Synergistic Interactions Between Nicotine and Cocaine or Methylphenidate Depend on the Dose of Dopamine Transporter Inhibitor

Autori
Gerasimov, Madina R. ; Franceschi, Maja ; Volkow, Nora D. ; Rice, Onarae ; Schiffer, Wynne K. ; Dewey, Stephen L.

Izvornik
Synapse (0887-4476) 38 (2000), 4; 432-437

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
dopamine ; addiction ; Ritalin ; ADHD ; microdialysis

Sažetak
There is a greater prevalence of cigarette smoking among cocaine dependent individuals and hyperactive children treated with stimulants (e.g., methylphenidate, MP. However, little is known about the neurochemical basis of the interaction between nicotine and cocaine or MP. It is thought that the reinforcing effects of cocaine and MP are due partly to increases in synaptic DA in the nucleus accumbens (NAc). These measurable increases are secondary to the blockade of the DA transporter. In contrast, nicotine stimulates acetylcholine receptors located presynaptically on dopaminergic projections from the ventral tegmental area (VTA) to the NAc and increases DA transmission. Here we investigate the effects of nicotine on NAc DA in animals simultaneously injected with cocaine or MP. Our findings suggest that the degree of DA transporter (DAT) occupancy contributes to the synergistic interaction between nicotine and cocaine or MP.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA