Naslov
Circulating dipeptidyl peptidase-4 activity is associated with diabetic retinopathy in type 1 diabetic patients

Autori
Blaslov, Kristina ; Bulum, Tomislav ; Duvnjak, Lea

Izvornik
European journal of ophthalmology (1120-6721) 25 (2015), 4; 328-332

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
diabetic retinopathy; dipeptidyl peptidase-4; type 1 diabetes mellitus

Sažetak
Diabetic retinopathy (DR) is the most frequent complication among type 1 diabetic (T1DM) patients. Dipeptidyl peptidase-4 (DPP-4) is protease with elevated ubiquitously expression and activity in T1DM subjects. Several studies indicate that DPP-4 inhibitors might have beneficial effect on nonproliferative retinopathy (NPR) development as well as on its progression to proliferative retinopathy (PR). We aimed to explore the relationship between serum DPP-4 activity and DR in T1DM patients.This cross-sectional recruited 44 T1DM patients. DPP-IV activity was measured by a colorimetric assay procured from Sigma, St. Louis, MO, USA in a microplate reader. Photodocumented retinopathy status was made according to the EURODIAB protocol. There were 28 (63.6%) male patients, mean age 45.36 years, diabetes duration 23.71 years, glycated haemoglobin A1c (HbA1c) of 7.4%. They were stratified into two groups according to retinopathy prevalence. Group 1 comprised 14 (31.85%) with DR absence while the second group consisted of 30 (68.15%) patients with both PR and NPR prevalence. Group 1 had lower fasting serum DPP-4 activity (25.85 vs 33.84 U/L, p<0.001) when compared to second group. In the binary logistic regression model adjusted for age, gender, diabetes duration and the HbA1c level, DPP-4 activity was associated with DR prevalence (OR 1.887 (1.073-3.321)). Serum DPP-4 activity may be independently associated with both DR types in T1DM patients. Further study investigation are warranted to elucidate whether there is a an association between DPP4 activity and DR severity and/or progression.

Izvorni jezik
Engleski

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