Naslov
Does personality play a relevant role in the placebo effect?

Autori
Jakšić, Nenad ; Aukst-Margetić, Branka ; Jakovljević, Miro

Izvornik
Psychiatria Danubina (0353-5053) 25 (2013), 1; 17-23

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, ostalo

Ključne riječi
placebo ; personality ; situation-personality interaction ; optimism ; endogenous opioids ; dopamine

Sažetak
Subjective factors influencing placebo response have been a focus of numerous theoretical conceptualizations and empirical research. one such pactor, inđdividual's personality has been linked to different clinical conditions, their expressions and treatment outcomes. Thus, there is little surprise many ressearches have tried to identify placebo-prone personality over the years. Because of certain methodological and conceptualč issues of the earlier of the earlier studies, these have not been very fruitful. However, recentscientific endeavours, facilitated by improved experimental designs and neuroimaging technology, have 'reignited the old fires'. It is now suggested that studies exploring the placebo-related personality traits, such as optimis/pessimism, neuroticism, and novelty seeking need to take into accout situational variables (e.g. positive or negative expectations, patient-clinicial reraltionship) and relevant underlying neurobiological mechanisms (e.g. endogenous opioid and dopaminergic systems). Even though many questions still remain to be answered, such as the indetification of different situational variables interacting with personality traits, exploration and better understanding of placebo-related personality would facilitate the use of placebo in clinical practice and improve the methodology of clinical trials.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA