Naslov
New generation vs. first geenration antipsychotics debate: pragmatic clinical trials and practice-based evidence

Autori
Jakovljević, Miro

Izvornik
Psychiatria Danubina (0353-5053) 21 (2009), 4; 446-452

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, ostalo

Ključne riječi
antipsychotics; effectiveness; clinical trials; personalized medicine

Sažetak
There has been significant confusion about the relative advantage of new generation antipsychotics over first geenration antipsychotics as well as of clinica ltrials performed to evaluae their efficacy vs. those designed to evaluate their effectiveness. Pragmatic of effectiveness clinical trials like CATIE and CUtLASS sponsored by governments have challenged the current worldview of the greater advantages of new generation over first generation antipsychotics and suggested more clinical applicability of older antipsychotics. Public policy regarding the roleand place of modeern antipsyxchotics in schizophrenia treatment is usually guided by the imperfect staste of clinical trials and by economic constraints. The right question is not wheter new generation antipsychotics are better than the first generation antipsychotics in terms of effectiveness, tolerability and safety. How to reach personalized, evidence based and value oriented decision making in the complex treatment of schizophrenia and other psychotic disorders, that is the question now. Personalized medicine in psychiatry is not possible without the availability of enough number of different modern antipsychotics.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA