Pregled bibliografske jedinice broj: 735088
The antimetastatic effect of macrophages restored by indomethacin : concomitant tumor immunity model
The antimetastatic effect of macrophages restored by indomethacin : concomitant tumor immunity model // Collegium antropologicum, 34 (2010), 3; 899-904 (međunarodna recenzija, članak, znanstveni)
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Naslov
The antimetastatic effect of macrophages restored by indomethacin : concomitant tumor immunity model
Autori
Kušan Jukić, Marija ; Tikvica Luetić, Ana ; Lukinović-Škudar, Vesna ; Andreis, Igor
Izvornik
Collegium antropologicum (0350-6134) 34
(2010), 3;
899-904
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
macrophages; concomitant immunity; mammary carcinoma; prostaglandins
Sažetak
The role of macrophages acting as immunologic antitumor effectors and promoters of tumor growth are poorly understood as yet. We investigated the role of macrophage in model of concomitant immunity (CI), a phenomenon of secondary tumor rejection during the primary tumor growth. It has been shown that the period of CI weakening can coincide with appearance of tumor metastases. We used mammary carcinoma (MC) artificial lung metastases to evaluate the influence of macrophages from various period of CI on the development of metastases in mice. Our results indicated that macrophages are responsible for the late period of CI weakening and suppression. To investigate weather prostaglandins can mediate suppressive effect of macrophages we used experiments with indomethacin and we found that inhibition of prostaglandin E2 synthesis by indomethacin restored antimetastatic effect of concomitant immune macrophages.
Izvorni jezik
Engleski
Znanstvena područja
Temeljne medicinske znanosti
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Social Science Citation Index (SSCI)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE
Uključenost u ostale bibliografske baze podataka::
- Abstracts in Anthropology
- Anthropological Literature
- EMBASE (Excerpta Medica)
- IBSS - The International Bibliography of the Social Sciences
- International Bibliography of the Social Sciences (IBSS)
- LLBA: Linguistics and Language Behavior Abstracts
- MEDLINE
- ERIH
- HRČAK
- CIRS
- JCR_SSS
- Index medicus
- PubMed
- ROAD
- SCOPUS
- SocINDEX
