Naslov
Gastric lesion development in normal and pylorus ligated rats after cervical vagotomy

Autori
Ćorić, Valentina ; Čulig, Josip ; Zoričić, Ivan ; Sallmani, Ahmet ; Mikulandra, Simon ; Bogdan, Stjepan ; Šimičević, Velimir ; Bulić, Krešimir ; Kolega, Marko ; Derniković, Krešimir ; Đačić, Sanja ; Karakas, Ivan ; Seiwerth, Sven ; Grabarević, Željko ; Sikirić, Predrag ; Petek, Marijan ; Ručman, Rudolf ; Jelić, Ivan

Izvornik
Journal of physiology (Paris) (0928-4257) 87 (1993), 5; 335-337

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
gastric lesion ; pylorus ; cervical vagotomy ; pylorus ligation ; aggravation ; death

Sažetak
The main purpose of this study was to further investigate the effects of vagotomy on gastric lesion development. In contrast to the usual subdiaphragmal vagotomy, a different vagotomy at the level of the trigonum caroticum was used both alone and in combination with pylorus ligation (done immediately after vagal transection). The animals were killed 15 min. 30 min, 1 h and 6 f following vagotomy. No damaging effects of sham- vagatomy, or obvious negative effects of cervical vagotomy were noted. Prominent lesions appeared after 1 h in rats subjected to cervical vagotomy and significantly increased lesions in the early period of pylorus ligation were noted. No further aggravation in pylorus ligated rats (even an apparent amelioration at 1-h interval) and no lesions in rats with cervical vagotomy in the latter period could be explained in terms of a lack of reactivity due to exhaustion preceding fatal outcome. Consistent with this, the rats subjected to cervical vagotomy died shortly after the 6-h period.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti

POVEZANOST RADA