Naslov
A new gastric juice peptide, BPC. An overview of the stomach-stress-organoprotection hypothesis and beneficial effects of BPC

Autori
Sikirić, Predrag ; Petek, Marijan ; Ručman, Rudolf ; Seiwerth, Seven ; Grabarević, Željko ; Rotkvić, Ivo ; Turković, Branko ; Jagić, Vjekoslav ; Mildner, Boris ; Duvnjak, Marko ; Lang, Nada ; Danilović, Žarko ; Cviko, Aida ; Kolega, Marko ; Sallmani, Ahmed ; Đačić, Sanja ; Bura, Miljenko ; Brkić, Tomislav ; Banić, Marko ; Dodig, Milan ; Ćorić, Vedran ; Šimičević, Velimir ; Veljača, Marija ; Erceg, Damir ; Ježek, Davor ; Simunić- Banek, Ljerka ; Skroza, N. ; Bulić, Krešimir ; Buljat, Gojko ; Hanževački, Miroslav ; Orihovac, V. ; Lučinger, Dražen ; Čulig, Josip ; Šeparović, Jadranka ; Marović, Anton ; Miše, Stjepan ; Suchanek, Ernest ; Matoz, Wendy ; Perović, Darko ; Gjurašin, Miroslav ; Mikulandra, Simon ; Derniković, Krešimir ; Ćuk, Višeslav ; Karakas, Ivan

Izvornik
Journal of physiology (Paris) (0928-4257) 87 (1993), 5; 313-327

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
organoprotection ; link-stomach ; stomach organoprotective stress response ; new gastric juice peptide BPC ; BPC 157 ; BPC organoprotection ; organoprotective mediator ; organoprotective agents ; pentadecapeptide

Sažetak
The possibility that the stomach, affected by general stress, might initiate a counter-response has not until recently been considered in theories of stress. We suggest that the stomach, as the most sensitive part of the gastrointestinal tract and the largest neuroendocrine organ in the body, is crucial for the initiation of a full stress response against all noxious stress pathology. The end result would be a strong protection of all organs invaded by ‘stress’. Consistent with this assumption, this coping response is best explained in terms of ‘organoprotection’. Endogenous organoprotectors (eg prostaglandins, somatostatin, dopamine) are proposed as mediators. Such an endogenous counteraction could even be afforded by their suitable application. A new gastric juice peptide, Mr 40 000, named BPC, was recently isolated. Herein, a 15 amino acid fragment (BPC 157), thought to be essential for its activity, has been fully characterized and investigated. As has been demonstrated for many organoprotective agents using different models of various tissue lesions, despite the poorly understood final mechanism, practically all organ systems appear to benefit from BPC activity. These effects have been achieved in many species using very low dosages (mostly μg and ng/kg range) after ip, ig, and intramucosal (local) application. The effect was apparent already after one application. Long lasting activity was also demonstrated. BPC was highly effective when applied simultaneously with noxious agents or in already pathological, as well as chronical, conditions. Therefore, it seems that BPC treatment does not share any of the so far known limitations for ‘conventional organoprotectors’. No influence on different basal parameters and no toxicity were observed. These findings provide a breakthrough in stress theory, BPC, as a possible endogenous free radical scavenger and organoprotection mediator, could be a useful prototype of a new class of drugs, organoprotective agents.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti

POVEZANOST RADA