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Pregled bibliografske jedinice broj: 734542

Genome-wide association study of cardiac structure and systolic function in African Americans : the Candidate Gene Association Resource (CARe) study

Fox, E.; Musani S.K.; Barbalić, Maja; Lin, H.; Yu, B.; Ogunyankin, K.O.; Smith, N.L.; Kutlar, A.; Glazer, N.L.; Post, W.S. et al.
Genome-wide association study of cardiac structure and systolic function in African Americans : the Candidate Gene Association Resource (CARe) study // Circulation. Cardiovascular genetics, 6 (2013), 1; 37-46 doi:10.1161/CIRCGENETICS.111.962365 (međunarodna recenzija, članak, znanstveni)

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Naslov
Genome-wide association study of cardiac structure and systolic function in African Americans : the Candidate Gene Association Resource (CARe) study

Autori
Fox, E. ; Musani S.K. ; Barbalić, Maja ; Lin, H. ; Yu, B. ; Ogunyankin, K.O. ; Smith, N.L. ; Kutlar, A. ; Glazer, N.L. ; Post, W.S. ; Paltoo, D.N. ; Dries, D.L. ; Farlow, D.N. ; Duarte, C.W. ; Kardia, S.L. ; Meyers, K.J. ; Sun, Y.V. ; Arnett, D.K. ; Patki, A.A. ; Sha, J, ; Cui, X. ; Samdarshi, T, E, ; Penman, A.D. ; Bibbins-Domingo, K. ; Bůžková, P. ; Benjamin, E.J. ; Bluemke, D.A. ; Morrison A.C. ; Heiss, G. ; Carr, J.J. ; Tracy, R.P. ; Mosley, T.H. ; Taylor, H.A. ; Psaty, B.M. ; Heckbert, S.R. ; Cappola, T.P. ; Vasan, R.S.

Izvornik
Circulation. Cardiovascular genetics (1942-325X) 6 (2013), 1; 37-46

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
echocardiography; ethnic; genome-wide association studies; Left atrium genetics; left ventricular mass genetics

Sažetak
Using data from 4 community-based cohorts of African Americans, we tested the association between genome-wide markers (single-nucleotide polymorphisms) and cardiac phenotypes in the Candidate-gene Association Resource study. Among 6765 African Americans, we related age, sex, height, and weight-adjusted residuals for 9 cardiac phenotypes (assessed by echocardiogram or magnetic resonance imaging) to 2.5 million single-nucleotide polymorphisms genotyped using Genome-wide Affymetrix Human SNP Array 6.0 (Affy6.0) and the remainder imputed. Within the cohort, genome-wide association analysis was conducted, followed by meta-analysis across cohorts using inverse variance weights (genome-wide significance threshold=4.0 ×10(-7)). Supplementary pathway analysis was performed. We attempted replication in 3 smaller cohorts of African ancestry and tested lookups in 1 consortium of European ancestry (EchoGEN). Across the 9 phenotypes, variants in 4 genetic loci reached genome-wide significance: rs4552931 in UBE2V2 (P=1.43×10(-7)) for left ventricular mass, rs7213314 in WIPI1 (P=1.68×10(-7)) for left ventricular internal diastolic diameter, rs1571099 in PPAPDC1A (P=2.57×10(-8)) for interventricular septal wall thickness, and rs9530176 in KLF5 (P=4.02×10(-7)) for ejection fraction. Associated variants were enriched in 3 signaling pathways involved in cardiac remodeling. None of the 4 loci replicated in cohorts of African ancestry was confirmed in lookups in EchoGEN. In the largest genome-wide association study of cardiac structure and function to date in African Americans, we identified 4 genetic loci related to left ventricular mass, interventricular septal wall thickness, left ventricular internal diastolic diameter, and ejection fraction, which reached genome-wide significance. Replication results suggest that these loci may be unique to individuals of African ancestry. Additional large-scale studies are warranted for these complex phenotypes.

Izvorni jezik
Engleski



POVEZANOST RADA

Profili:

Avatar Url Maja Barbalić (autor)

Poveznice na cjeloviti tekst rada:

doi circgenetics.ahajournals.org

Citiraj ovu publikaciju:

Fox, E.; Musani S.K.; Barbalić, Maja; Lin, H.; Yu, B.; Ogunyankin, K.O.; Smith, N.L.; Kutlar, A.; Glazer, N.L.; Post, W.S. et al.
Genome-wide association study of cardiac structure and systolic function in African Americans : the Candidate Gene Association Resource (CARe) study // Circulation. Cardiovascular genetics, 6 (2013), 1; 37-46 doi:10.1161/CIRCGENETICS.111.962365 (međunarodna recenzija, članak, znanstveni)
Fox, E., Musani S.K., Barbalić, M., Lin, H., Yu, B., Ogunyankin, K., Smith, N., Kutlar, A., Glazer, N. & Post, W. (2013) Genome-wide association study of cardiac structure and systolic function in African Americans : the Candidate Gene Association Resource (CARe) study. Circulation. Cardiovascular genetics, 6 (1), 37-46 doi:10.1161/CIRCGENETICS.111.962365.
@article{article, author = {Fox, E. and Barbali\'{c}, Maja and Lin, H. and Yu, B. and Ogunyankin, K.O. and Smith, N.L. and Kutlar, A. and Glazer, N.L. and Post, W.S. and Paltoo, D.N. and Dries, D.L. and Farlow, D.N. and Duarte, C.W. and Kardia, S.L. and Meyers, K.J. and Sun, Y.V. and Arnett, D.K. and Patki, A.A. and Cui, X. and Penman, A.D. and Bibbins-Domingo, K. and B\r{u}\v{z}kov\'{a}, P. and Benjamin, E.J. and Bluemke, D.A. and Heiss, G. and Carr, J.J. and Tracy, R.P. and Mosley, T.H. and Taylor, H.A. and Psaty, B.M. and Heckbert, S.R. and Cappola, T.P. and Vasan, R.S.}, year = {2013}, pages = {37-46}, DOI = {10.1161/CIRCGENETICS.111.962365}, keywords = {echocardiography, ethnic, genome-wide association studies, Left atrium genetics, left ventricular mass genetics}, journal = {Circulation. Cardiovascular genetics}, doi = {10.1161/CIRCGENETICS.111.962365}, volume = {6}, number = {1}, issn = {1942-325X}, title = {Genome-wide association study of cardiac structure and systolic function in African Americans : the Candidate Gene Association Resource (CARe) study}, keyword = {echocardiography, ethnic, genome-wide association studies, Left atrium genetics, left ventricular mass genetics} }
@article{article, author = {Fox, E. and Barbali\'{c}, Maja and Lin, H. and Yu, B. and Ogunyankin, K.O. and Smith, N.L. and Kutlar, A. and Glazer, N.L. and Post, W.S. and Paltoo, D.N. and Dries, D.L. and Farlow, D.N. and Duarte, C.W. and Kardia, S.L. and Meyers, K.J. and Sun, Y.V. and Arnett, D.K. and Patki, A.A. and Cui, X. and Penman, A.D. and Bibbins-Domingo, K. and B\r{u}\v{z}kov\'{a}, P. and Benjamin, E.J. and Bluemke, D.A. and Heiss, G. and Carr, J.J. and Tracy, R.P. and Mosley, T.H. and Taylor, H.A. and Psaty, B.M. and Heckbert, S.R. and Cappola, T.P. and Vasan, R.S.}, year = {2013}, pages = {37-46}, DOI = {10.1161/CIRCGENETICS.111.962365}, keywords = {echocardiography, ethnic, genome-wide association studies, Left atrium genetics, left ventricular mass genetics}, journal = {Circulation. Cardiovascular genetics}, doi = {10.1161/CIRCGENETICS.111.962365}, volume = {6}, number = {1}, issn = {1942-325X}, title = {Genome-wide association study of cardiac structure and systolic function in African Americans : the Candidate Gene Association Resource (CARe) study}, keyword = {echocardiography, ethnic, genome-wide association studies, Left atrium genetics, left ventricular mass genetics} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

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