Naslov
Ultrastructure of the chorionic villi in anembryonic pregnancy

Autori
Grbeša, Đurđica ; Latin, Višnja

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, ostalo

Izvornik
1st Congress of the Croatian Society for Electron Microscopy with International participation / Vranešić, Đuro - Zagreb, 1999, 35-36

Skup
1st Congress of the Croatian Society for Electron Microscopy

Mjesto i datum
Zagreb, Hrvatska, 13.05.1999. - 16.05.1999

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Human placenta; chorionic villi; anembryonic pregnancy

Sažetak
In our previous light microscopic histomorphological research we have analysed quantitative by stereological methods the villous structure of placentas in anembyonic pregnancies. The results have shown quantitative rather than qualitative abnormalities of villous stroma and blood vessels.The trophoblast didn, t differe from that in early stages of normal placental development. The purpose of this study is to analysethe ultrastructure of villous components in anembryonic pregnancies in related to normal placentas of the appropriate gestatinal age.The aim is to determine if ultrastructural alterations of villihave developed. The study group comprised 8 pregnant women who gastational ranged from 7 to 10 weeks from the last menstrual period. In 4 women the anembryionic pregnancy was diagnosed ultrasonically. The control group consisted of 4 healthy women with normal pregnancy terminated after obtaining appropriate consent. Placental tissue specimens were fixed by immersion with paraformaldehyde (4%) added to a 0, 1M phosphate buffer, followed by OsO4, dehydrated in acetone and embeded in Durcopan (Fluka). Ultrathin sections were stained with uranyl acetate and examined with a Zeiss (Opton) 902A electron microscope.The most striking feature of placentas in anembryonic pregnancies was the virtual failure of villous stroma to show any significant degree of morphologic differentiation.It consisted of only a limited number of mesenchymal cells, without Hofbauer cells or blood vessels. Reduced villous vascularization could be considered to represent the expression of the reduced growth potential in early pregnancy failure.The functional implication would be decreased transport of nutrients to the embryo that could be responsible of its growth retardation and decreased viability.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti

POVEZANOST RADA