Naslov
Does estrogen stimulates the pathogenic sort of anticardiolipin antibodies?

Autori
Martinović Kaliterna, Dušanka ; Radić, Mislav ; Ljutić, Dragan

Izvornik
Israel medical association journal (1565-1088) 16 (2014), 3; 197-198

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pismo, ostalo

Ključne riječi
sex hormones ; anticardiolipin antibodies

Sažetak
Our results provide a little evidence that hyper estrogenic levels in premenopausal SLE women are associated with an increased risk of APS and cardiovascular manifestation. An increased risk of hyper estrogenic levels was expected based on the results of other research, particularly the extensive experimental studies of estrogen and androgen exposure in relation to disease progression in mice. Gonadoctomized or intact male and female nonautoimmune C57BL/6 mice treated with exogenous estrogen express aCL. These antibodies persisted for months after estrogen has been terminated, but there was no proof that these antibodies have had a pathologic role. Some antibodies in humans may persist for years without evidence off autoimmune tissue accident and it is the question what can force aCL to become pathologic. It is already proven that estrogens enhance thrombotic events in SLE patients, so we calculate that the estrogens especially stimulate the pathological sort of aCL. This observation, if confirmed by other studies, raises interesting questions about the interrelation between estrogens and autoimmunity, with a potential impact on the risk of thrombosis and cardiovascular disease.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA