Naslov
Impact of Ceftriaxone de-restriction on the occurrence of ESBL-positive bacterial strains and antibiotic consumption

Autori
Škrlin, Jasenka ; Bačić Vrca, Vesna ; Marušić, Srećko ; Ćirić-Crncec, M. ; Mayer, L.

Izvornik
Journal of chemotherapy (1120-009X) 23 (2011), 6; 341-344

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
antibiotic policy ; antibiotic use ; cephalosporins ; ceftriaxone ; ESBLs ; resistance

Sažetak
As a cost-saving measure, the Drug and Therapeutics Committee (DTC) removed ceftriaxone from the list of restricted antibiotics in May, 2008, which permitted its use as a first-line antibiotic. To evaluate the impact of this change, the occurrence of extended-spectrum beta-Iactamase (ESBL)- positive bacterial strains and antibiotic consumption were monitored for 2 years before and after the intervention. In the post- intervention period, ceftriaxone utilization increased, while total antibiotic utilization did not change significantly. The utilization of all restricted antibiotics decreased (p <0.05) in the post- intervention period. Utilization of carbapenems increased (p <0.05), while utilization of quinolones increased nonsignificantly. The density of resistant ESBLs increased (p = 0.001) from 0.99 to 1.34 per 1000 bed-days fromthe pre- to the post- intervention period. Ceftriaxone use was significantly correlated with ESBL occurrence (p <0.005). It can be concluded that ceftriaxone de- restriction increased the occurrence of ESBLs and the utilization of carbapemens.

Izvorni jezik
Engleski

Znanstvena područja
Farmacija

POVEZANOST RADA