Naslov
Genetic structure of Croatian Roma population – analysis of leptin system genes’ polymorphisms

Autori
Ivankov, Ana-Maria ; Petrić, Sara ; Barešić, Ana ; Tomas, Željka ; Zajc Petranović, Matea ; Škarić-Jurić, Tatjana ; Peričić Salihović, Marijana ; Smolej Narančić, Nina ; Janićijević, Branka

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
V Congress of the Serbian Genetic Society / Vasiljević, Branka ; Mladenović Drinić, Snežana - Beograd : Akademska izdanja, 2014, 42-42

ISBN
978-86-87109-10-0

Skup
V Congress of the Serbian Genetic Society

Mjesto i datum
Beograd, Srbija, 28.09.2014. - 02.10.2014

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
leptin system; Roma; SNP; admixture; climate

Sažetak
Genotypic and phenotypic differences between populations can be created by adaptation to different living conditions such as climate. Recently it was found that the frequencies of some genetic variants involved in metabolic pathways are correlated with climate zones. Since the Roma are a population which descends from area belonging to different climate zone then they presently live the goal of this study was to determinate how it is reflected in their gene pool. Since the leptin system is recognized as important regulator of metabolism we analyzed 29 SNPs associated with leptin system in Croatian Roma population. Allelic frequencies of these loci are compared between Romani and other worldwide populations. We found out that allele frequency distribution in worldwide populations follows isolation by distance model and 6 investigated loci show significant correlation with latitude as a proxy for climate conditions. Investigated loci in Roma gene pool reflect process of admixture with Asian and European populations.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Javno zdravstvo i zdravstvena zaštita, Etnologija i antropologija

POVEZANOST RADA