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Pregled bibliografske jedinice broj: 731549

Localization of lanosterol 14α-demethylase in round and elongated spermatids of the mouse testis: an immunoelectron microscopic and stereological study

Cotman, Marko; Rozman, Damjana; Banek, Ljerka; Ježek, Davor
Localization of lanosterol 14α-demethylase in round and elongated spermatids of the mouse testis: an immunoelectron microscopic and stereological study // Pflügers Archiv, 442 (2001), S1; r167-r168 doi:10.1007/s004240100011 (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 731549 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Localization of lanosterol 14α-demethylase in round and elongated spermatids of the mouse testis: an immunoelectron microscopic and stereological study

Autori
Cotman, Marko ; Rozman, Damjana ; Banek, Ljerka ; Ježek, Davor

Izvornik
Pflügers Archiv (0031-6768) 442 (2001), S1; R167-r168

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
citochrome P450; CYP51; MAS; immunogold labelling; testis

Sažetak
Lanosterol 14α-demethylase (CYP51) is a microsomal cytochrome P450 enzyme involved in the postsqualene cholesterol biosynthetic pathway. PYP51 removes 14α-methyl group from lanosterol, forming FF-MAS (folicular fluid meiosis activating sterol) which accumulates in gonads. The goal of our study is to determine the expression of CYP51 protein in the male gonad. Using electron microscopic immunogold techniques, CYP51 is localised on inner and outer acrosomal membranes of male germ cells, the round end elongated spermatids. Significance od CYP51 localization on the acrosome which is a Golgi-derived organelle is not known, but we propose that CYP51-formed FF-MAS can function as a signalling sterol during fertilization.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Veterinarska medicina



POVEZANOST RADA

Ustanove:
Medicinski fakultet, Zagreb

Profili:

Avatar Url Ljerka Banek (autor)

Avatar Url Davor Ježek (autor)

Poveznice na cjeloviti tekst rada:

doi link.springer.com

Citiraj ovu publikaciju:

Cotman, Marko; Rozman, Damjana; Banek, Ljerka; Ježek, Davor
Localization of lanosterol 14α-demethylase in round and elongated spermatids of the mouse testis: an immunoelectron microscopic and stereological study // Pflügers Archiv, 442 (2001), S1; r167-r168 doi:10.1007/s004240100011 (međunarodna recenzija, članak, znanstveni)
Cotman, M., Rozman, D., Banek, L. & Ježek, D. (2001) Localization of lanosterol 14α-demethylase in round and elongated spermatids of the mouse testis: an immunoelectron microscopic and stereological study. Pflügers Archiv, 442 (S1), r167-r168 doi:10.1007/s004240100011.
@article{article, author = {Cotman, Marko and Rozman, Damjana and Banek, Ljerka and Je\v{z}ek, Davor}, year = {2001}, pages = {r167-r168}, DOI = {10.1007/s004240100011}, keywords = {citochrome P450, CYP51, MAS, immunogold labelling, testis}, journal = {Pfl\"{u}gers Archiv}, doi = {10.1007/s004240100011}, volume = {442}, number = {S1}, issn = {0031-6768}, title = {Localization of lanosterol 14α-demethylase in round and elongated spermatids of the mouse testis: an immunoelectron microscopic and stereological study}, keyword = {citochrome P450, CYP51, MAS, immunogold labelling, testis} }
@article{article, author = {Cotman, Marko and Rozman, Damjana and Banek, Ljerka and Je\v{z}ek, Davor}, year = {2001}, pages = {r167-r168}, DOI = {10.1007/s004240100011}, keywords = {citochrome P450, CYP51, MAS, immunogold labelling, testis}, journal = {Pfl\"{u}gers Archiv}, doi = {10.1007/s004240100011}, volume = {442}, number = {S1}, issn = {0031-6768}, title = {Localization of lanosterol 14α-demethylase in round and elongated spermatids of the mouse testis: an immunoelectron microscopic and stereological study}, keyword = {citochrome P450, CYP51, MAS, immunogold labelling, testis} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

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