Naslov
Genetic risk factors in patients with acute ischemic stroke: the role of PPARG and IL-6

Autori
Bazina, Antonela ; Mismas, Antonija ; Bozina, Nada ; Skoric Krbot, Magdalena ; Poljakovic, Zdravka ; Sertic, Jadranka

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
European Journal of Neurology / - : Wiley-Blackwell, 2014, 206-206

Skup
Joint Congress of European Neurology

Mjesto i datum
Istanbul, Turska, 31.05.2014. - 03.06.2014

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
acute ischemic stroke; polymorphism; PPARG; IL-6

Sažetak
Background: Ischemic stroke is a multifactorial disease which includes interaction among various genetic and enviromental factors. Objective: The aim of the present study was to estimate possible associations of two analysed genes, peroxisome proliferator activated receptor-gama (PPARG) and interleukin-6 (IL-6) and their gene variability on ischemic stroke development in a patient group. Methods: Study included 301 subjects (114 patients and 187 healthy controls). Data on patients presenting with acute ischemic stroke, their earlier medical history and modifiable risk factors: (hypertension, hyperlipidaemia, high body mass, cigarette smoking, physical activity), were prospectively collected from January 2008 until January 2012. Genotyping was performed using PCR-RFLP based methods. Results: According to the results of comparisons of ndividual genotype against others, genotypes PPARG CC (p<0.001), IL-6 -174 GC (p<0.001¸) were statistically more frequent in the patient’s group. Patients had significantly higher BMI, higher blood pressure, and higher level of total cholesterol, LDL, triglycerides, lowered level of HDL, and elevated level of CRP. Study patient’s group recorded a higher proportion of men, and participants with a positive family history on cerebrovascular disease than in control group. Statistically significant association in patient group was found between IL-6 genotypes and levels of C reactive protein (÷2=9.728 ; df=2 ; p=0.009 ; ö=0.292). Elevated C- reactive protein was most common among patients with IL-6 174 GC genotype (p=0.009). Conclusion: PPARG CC and IL-6 174 GC gene polymorphism variants could be susceptibility factors for ischemic stroke development in patient group, particularly in males, in presence of hypertension and elevated CRP levels.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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