Naslov
Nonfrequent but well documented, rare and very rare HLA alleles observed in the Croatian population

Autori
Grubić, Zorana ; Burek Kamenarić, Marija ; Maskalan, Marija ; Štingl, Katarina ; Žunec, Renata

Izvornik
Tissue antigens (0001-2815) 84 (2014), 6; 560-564

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, kratko priopcenje, znanstveni

Ključne riječi
Common and well documented alleles; High resolution typing; Human Leucocyte Antigen; Polymorphism; Rare alleles

Sažetak
The aim of the study was to evaluate the presence of non-frequent, rare and very rare alleles among Croats and to estimate whether they are associated with specific alleles at other HLA loci. Haplotype analysis of non-frequent alleles detected in our sample supports the idea that different populations, although similar in some aspects regarding HLA allele and haplotype distribution, still have some unique characteristics. This is the case of A*01:02, B*39:10 and DRB1*13:32 which form haplotypes unreported to date among our subjects. Among 16 alleles so far observed only once in our population, six (A*24:41, B*07:02:28, B*35:03:03, B*39:40N, DRB1*13:23, and DRB1*14:111) belong to very rare alleles, two (B*44:16 and DRB1*01:31) belong to rare alleles according to the “Rare Alleles Detector” tool, while for the B*35:101:01 allele published data exist only in the IMGT/HLA database. There is no data available for any of those 16 alleles in the CWD allele catalogue 2.0.0.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA