Naslov
Inflammatory bowel disease and hyperbaric oxygenation

Autori
Mihalj, Martina ; Ugor, Emese ; Kellermayer, Zoltan ; Žulj, Marinko ; Berki, Timea ; Drenjančević, Ines

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, ostalo

Izvornik
Periodicum Biologorum / - Zagreb, 2013

Skup
3rd Congress of Croatian Physiological Society and 1st Regional Congress of the Physiological Societie

Mjesto i datum
Rijeka, Hrvatska, 13.09.2013. - 15.09.2013

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Hyperbaric oxygenation; colitis; BALB/c mice

Sažetak
Hyperbaric oxygenation (HBO2) has been widely used for treating wounds, patients suffering from stroke, gangrene, carbon monoxide poisoning, decompression sickness, and some other indications. It has been proposed that the beneficial effects of HBO2 are mediated through its anti-inflammatory action. In addition, recent studies in both animals and men showed that HBO2 ameliorates the course of experimentally induced colitis and inflammatory bowel disease, respectively. It was found that adoptive transfer or induction of CD4+CD25+FoxP3+ regulatory T cells (Treg) can prevent disease and reverse the course of established colitis. In the present study, we have assessed the effects of HBO2 on the frequencies of Treg in mLN of mice with DSS-induced colitis. In addition, we have followed frequencies of T and B cell lymphocytes in the mLN and spleen. Frequency of Treg in mLN increased significantly in DSS treated mice, and was reduced to control values after HBO2. In addition, DSS mice showed increased frequencies of B220+ B cells, followed by reduced frequency of CD3+ T cells. These effects were significantly reduced in DSS mice undergoing HBO2. Thus, the results of this study suggest that HBO2 affect inflammatory process during DSS induced colitis.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA