Naslov
Waist-to-height ratio is independently associated with chronic kidney disease in overweight type 2 diabetic patients

Autori
Blaslov, Kristina ; Bulum, Tomislav ; Duvnjak, Lea

Izvornik
Endocrine research (0743-5800) 40 (2015), 4; 194-198

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
chronic kidney disease; central obesity; type 2 diabetes mellitus; waist-to-height ratio

Sažetak
Chronic kidney disease (CKD) is one of the most serious complications in obesity induced type 2 diabetes mellitus (T2DM). Body mass index (BMI), waist to hip ratio (WHR), waist circumference (WC) and waist to height ratio (WHtR) are recognised as sensitive obesity measures. We aimed to investigate the association of BMI, WC, WHR and WHtR with CKD prevalence in overweight T2DM patients. We obtained 125 overweight T2DM patients coming for their in-patient annual visit. Metabolic profiles and anthropometric indices were measured and calculated. Urine albumin excretion (UAE) was determined as the mean of 24-h urine from two consecutive days. Serum creatinine was measured from fasting blood sample in order to calculate the estimated glomerular filtration rate (eGFR) using the Chronic Kidney Disease Epidemiology Collaboration formula. Patients were divided in two groups according to CKD prevalence. Thirty six (28.8%) patients met diagnostic criteria for CKD. The WHtR and WC were higher in the group with CKD. WHtR correlated positively with UAE (r=0.828, p<0.001) and negatively with eGFR (r=-0.262, p=0.015). No significant correlation was observed with WC in relation to UAE (p=0.335) nor eGFR (p=0.121). WHtR yielded the significant and great OR in association to nephropathy after adjustment for all confounding risk factors. WHtR might be of a greater importance in association to CKD compared to other anthropometric parameters that indicate central obesity. Whether it is a best measure of central obesity and its exact role in CKD pathology is yet to be investigated.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA