Naslov
Plasma cholinesterase activity in patients with uterine cervical cancer during radiotherapy

Autori
Bradamante, Vlasta ; Šmigovec, Eva ; Buković, Damir ; Geber, Juraj ; Matanić, Davor

Izvornik
Collegium antropologicum (0350-6134) 24 (2000), 2; 373-380

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Plasma cholinesterase; uterine cervical cancer; radiotherapy

Sažetak
The objectives of this study were to investigate: 1) the activity of pseudocholinesterase (PChE) in patients with uterine cervical cancer in different stages (uterine cervical carcinoma in stages IIb and III and recurrent cervical carcinoma in stages III and IV a, b) and to compare it to the enzyme activity in patients with benign tumour if the uterus, and 2) the effects of radiotherapy on enzyme activity in those patients with uterine cervical carcinoma for which the chosen treatment was radical radiotherapy. Thirty patients with uterine cervical carcinoma in stages II b and III (Group A), sixteen patients with recurrent cervical carcinoma in stages III and IV a, b (Group B) and thirty-eight patients with benign tumours of the uterus (control, Group C) were evaluated and their PChE activity was determined prior to any treatment (pre-therapy enzyme activity). All eight-four patients were free of any liver disease. The results have shown that tje patients of Group A had the pre-therapy PChE activity practically identical to those in Group C, but patients of Group B had significantly lower values of PChE with respect to enzyme activities of Groups A and C (p<0.001). That is to say, PChE activity was influenced by the extent to which the malignancy had spread. Radical radiotherapy (up tp 8 weeks in doses higher than 50 Gy into point A ; average 80 Gy) which was the chosen treatment only for patients from Group A did not cause a significant inhibition of PChE activity in any patients in comparison with their control values. With regard to the role of PChE in hydrolysis of succinylcholine, our results about the influence of the malignant disease and the radiotherapy on PChE activity are clinically significant.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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