Naslov
Comparison of metabolic and endocrine parameters in patients with moderate and severe obstructive sleep apnea

Autori
Božić, Joško ; Galić, Tea ; Šupe-Domić, Daniela ; Ivković, Natalija ; Tičinović Kurir, Tina ; Valić, Zoran ; Đogaš, Zoran

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Journal of Sleep Research / Derk-Jan Dijk - : European Sleep Research Society, 2014, 207-207

Skup
22nd Congress of the European Sleep Research Society

Mjesto i datum
Talin, Estonija, 16.09.2014. - 20.09.2014

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Obstructive sleep apnea ; HPAC axis

Sažetak
The pathophysiology of obstructive sleep apnea syndrome (OSAS) has been associated with dysregulation of the hypothalamic pituitary adrenal axis and has been linked to abnormal glucose metabolism and increased diabetes risk. The aim of the current study was to compare parameters of glucose metabolism and hormonal status between moderate OSA (apnea-hypopnea index (AHI):15–30) and severe OSA (AHI > 30) patients.A total of 56 OSA patients(24 moderate and 32 severe) underwent a full-night polysomnography, oral glucose tolerance test(OGTT) and blood sampling for various metabolic and endocrine parameters. Insulin resistance was assessed by the homeostatic model assessment index of insulin resistance(HOMA-IR index).Fasting plasma glucose level(5.05±
0.
54 vs.5.41±0.67 mmol/L ; P = 0.037), HbA1c (5.4
±0.2 vs.5.7±
0.3% ; P = 0.001) and HOMA-IR index (2.68
±2.08 vs. 4.61±
3.71 ; P = 0.026) were significantly lower in moderate OSA patients in comparison with severe OSA patients. There were no statistically significant difference in insulin and postprandial glucose levels between groups. Levels of morning plasma cortisol were statistically higher in moderate OSA group(424±
145 nmol/L) comparing to severe OSA patients (303
±93 nmol/L ; P < 0.001).In conclusion we can state that the glucose metabolism was altered in both groups, but more pronou
nced in severe OSA patients while cortisol levels were higher in moderate OSA patients.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA