Naslov
Lungs lesions and anti-ulcer agents beneficial effect:Anti-ulcer agents pentadecapeptide BPC 157, ranitidine, omeprazole and atropine ameliorate lung lesion in rats

Autori
Stančić-Rokotov, Dinko ; Slobodnjak, Zoran ; Aralica, Josip ; Aralica, Gorana ; Perović, Darko ; Starešinić, Mario ; Gjurašin, Miroslav ; Anić, Tomislav ; Zoričić, Ivan ; Buljat, Gojko ; Prkačin, Ingrid ; Sikirić, Predrag ; Seiwerth, Sven ; Ručman, Rudolf ; Petek, Marijan ; Turković, Branko ; Kokić, Neven ; Jagić, Vjekoslav ; Boban-Blagaić, Alenka

Izvornik
Journal of physiology (Paris) (0928-4257) 95 (2001); 303 - 308

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Lung lesion; Anti-ulcer agents; Amelioration of lung lesion; Direct cytoprotective effect

Sažetak
Anti-ulcer agents may likely attenuate lesions outside the gastrointestinal tract, since they had protected gastrectomized rats (a "direct cytoprotective effect"). Therefore, their therapeutic potential in lung/stomach lesions were shown. Rats recived an intratracheal (i.t.) HCl instillation ((1.5 ml/kg HCl (pH 1.75)) (lung lesion), and an intragastric (i.g.) instillation of 96% ethanol (gastric lesion ; 1 ml/rat, 24 h after i.t. HCl instillation), than sacrificed 1 h after ethanol. Basically, in lung-injured rats, the subsequent ethanol-gastric lesion was markedly aggravated.This aggravation, however, in turn, did not affect the severity of the lung lesions in the further period, at least for 1 h of observation. Taking intratracheal HCl-instillation as time 0, a gastric pentadecapeptide, GEPPPGKPADDAGLV, M.W.1419, coded BPC 157 (10 microgram, 10 nanogram, 10 picogram), ranitidine (10 mg), atropine (10 mg), omeprazole (10 mg), were given ((/kg, intraperitoneally (i.p.) )) (i) once, only prophylactically ((as a pre-treatment (at - 1 h) )), or as a co-treatment ((at 0)), or only therapeutically (at + 18 h or + 24 h) ; (ii) repeatedly, combining prophylactic/therapeutic regimens (( (- 1h)+(+24h) )) or (( (0)+ (+24h) )), or therapeutic/therapeutic regimens (( (+18h)+(+24h) )). For all agents, combining their prophylactic and salutary regimens (at - 1h/24h, or at 0/+24hh) attenuated lung lesions ; even if effect had been not seen alreadly whit a single application, it became prominent after repeated treatment.In single application studies, relative to controls, a co-treatment (except to omeprazole), a pre-treatment (at - 1h) (pentadecapeptide BPC 157 and atropine, but not ranitidine and omeprazole) regulary attenuated, while therapeutically, atropine (at +18h), pentadecapeptide BPC 157 highest dose and omeprazole at +24h), reversed the otherwise more severe lung lesion.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

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