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A genome-wide association study of anorexia nervosa

Boraska, Vesna; Franklin, C.S.; Floyd, J.A.; Thornton, L.M.; Huckins, L.M.; Southam, L.; Rayner, N.W.; Tachmazidou, I.; Klump, K.L.; Treasure, J. et al.
A genome-wide association study of anorexia nervosa // Molecular psychiatry, 19 (2014), 10; 1085-1094 doi:10.1038/mp.2013.187 (međunarodna recenzija, članak, znanstveni)

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Naslov
A genome-wide association study of anorexia nervosa

Autori
Boraska, Vesna ; Franklin, C.S. ; Floyd, J.A. ; Thornton, L.M. ; Huckins, L.M. ; Southam, L. ; Rayner, N.W. ; Tachmazidou, I. ; Klump, K.L. ; Treasure, J. ; Lewis, C.M. ; Schmidt, U. ; Tozzi, F. ; Kiezebrink, K. ; Hebebrand, J. ; Gorwood, P. ; Adan, R.A. ; Kas, M.J. ; Favaro, A. ; Santonastaso, P. ; Fernández-Aranda, F. ; Gratacos, M. ; Rybakowski, F. ; Dmitrzak-Weglarz, M. ; Kaprio, J. ; Keski-Rahkonen, A. ; Raevuori, A. ; Van Furth, E.F. ; Slof-Op 't Landt, M.C. ; Hudson, J.I. ; Reichborn-Kjennerud, T. ; Knudsen, G.P. ; Monteleone, P. ; Kaplan, A.S. ; Karwautz, A. ; Hakonarson, H. ; Berrettini, W.H. ; Guo, Y. ; Li, D. ; Schork, N.J. ; Komaki, G. ; Ando, T. ; Inoko, H. ; Esko, T. ; Fischer, K. ; Männik, K. ; Metspalu, A. ; Baker, J.H. ; Cone, R.D. ; Dackor, J. ; DeSocio, J.E. ; Hilliard, C.E. ; O'Toole, J.K. ; Pantel, J. ; Szatkiewicz, J.P. ; Taico, C. ; Zerwas, S. ; Trace, S.E. ; Davis, O.S. ; Helder, S. ; Bühren, K. ; Burghardt, R. ; de Zwaan, M. ; Egberts, K. ; Ehrlich, S. ; Herpertz-Dahlmann, B. ; Herzog, W. ; Imgart, H. ; Scherag, A. ; Scherag, S. ; Zipfel, S. ; Boni, C. ; Ramoz, N. ; Versini, A. ; Brandys, M.K. ; Danner, U.N. ; de Kovel, C. ; Hendriks, J. ; Koeleman, B.P. ; Ophoff, R.A. ; Strengman, E. ; van Elburg, A.A. ; Bruson, A. ; Clementi, M. ; Degortes, D. ; Forzan, M. ; Tenconi, E. ; Docampo, E. ; Escaramís, G.. ; Jiménez-Murcia, S ; Lissowska, J. ; Rajewski, A. ; Szeszenia-Dabrowska, N. ; Slopien, A. ; Hauser, J. ; Karhunen, L. ; Meulenbelt, I. ; Slagboom, P.E. ; Tortorella, A. ; Maj, M. ; Dedoussis, G. ; Dikeos, D. ; Gonidakis, F. ; Tziouvas, K. ; Tsitsika, A. ; Papezova, H. ; Slachtova, L. ; Martaskova, D. ; Kennedy, J.L. ; Levitan, R.D. ; Yilmaz, Z. ; Huemer, J. ; Koubek, D. ; Merl, E. ; Wagner, G. ; Lichtenstein, P. ; Breen, G. ; Cohen-Woods, S. ; Farmer, A. ; McGuffin, P. ; Cichon, S. ; Giegling, I. ; Herms, S. ; Rujescu, D. ; Schreiber, S. ; Wichmann, H.E. ; Dina, C. ; Sladek, R. ; Gambaro, G. ; Soranzo, N. ; Julia, A. ; Marsal, S ; Rabionet, R ; Gaborieau, V ; Dick, D.M. ; Palotie, A. ; Ripatti, S. ; Widén, E. ; Andreassen, OA ; Espeseth, T ; Lundervold, A ; Reinvang, I. ; Steen, V.M. ; Le Hellard, S. ; Mattingsdal, M. ; Ntalla, I. ; Bencko, V. ; Foretova, L. ; Janout, V. ; Navratilova, M. ; Gallinger, S. ; Pinto, D. ; Scherer, S.W. ; Aschauer, H. ; Carlberg, L. ; Schosser, A. ; Alfredsson, L. ; Ding, B. ; Klareskog, L. ; Padyukov, L. ; Courtet, P. ; Guillaume, S. ; Jaussent, I. ; Finan, C. ; Kalsi, G. ; Roberts, M. ; Logan, D.W. ; Peltonen, L. ; Ritchie, G.R. ; Barrett, J.C. ; Wellcome Trust Case Control Consortium 3 ; Estivill, X ; Hinney, A ; Sullivan, PF ; Collier, DA ; Zeggini, E ; Bulik, CM

Izvornik
Molecular psychiatry (1359-4184) 19 (2014), 10; 1085-1094

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
anorexia nervosa; body mass index; eating disorders; genome-wide association study; GWAS; metabolic

Sažetak
Anorexia nervosa (AN) is a complex and heritable eating disorder characterized by dangerously low body weight. Neither candidate gene studies nor an initial genome-wide association study (GWAS) have yielded significant and replicated results. We performed a GWAS in 2907 cases with AN from 14 countries (15 sites) and 14 860 ancestrally matched controls as part of the Genetic Consortium for AN (GCAN) and the Wellcome Trust Case Control Consortium 3 (WTCCC3). Individual association analyses were conducted in each stratum and meta-analyzed across all 15 discovery data sets. Seventy-six (72 independent) single nucleotide polymorphisms were taken forward for in silico (two data sets) or de novo (13 data sets) replication genotyping in 2677 independent AN cases and 8629 European ancestry controls along with 458 AN cases and 421 controls from Japan. The final global meta-analysis across discovery and replication data sets comprised 5551 AN cases and 21 080 controls. AN subtype analyses (1606 AN restricting ; 1445 AN binge–purge) were performed. No findings reached genome-wide significance. Two intronic variants were suggestively associated: rs9839776 (P = 3.01 × 10− 7) in SOX2OT and rs17030795 (P = 5.84 × 10− 6) in PPP3CA. Two additional signals were specific to Europeans: rs1523921 (P = 5.76 × 10−6) between CUL3 and FAM124B and rs1886797 (P = 8.05 × 10−6) near SPATA13. Comparing discovery with replication results, 76% of the effects were in the same direction, an observation highly unlikely to be due to chance (P=4×10− 6), strongly suggesting that true findings exist but our sample, the largest yet reported, was underpowered for their detection. The accrual of large genotyped AN case-control samples should be an immediate priority for the field.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Temeljne medicinske znanosti



POVEZANOST RADA

Projekti:
HRZZ-PD-02.03/68 - Analiza i interpretacija cjelogenomskih studija povezanosti: primjena u projektu 10,001 Dalmatinac

Ustanove:
Medicinski fakultet, Split

Profili:

Avatar Url Vesna Boraska Perica (autor)

Poveznice na cjeloviti tekst rada:

Pristup cjelovitom tekstu rada doi www.nature.com www.ncbi.nlm.nih.gov

Citiraj ovu publikaciju:

Boraska, Vesna; Franklin, C.S.; Floyd, J.A.; Thornton, L.M.; Huckins, L.M.; Southam, L.; Rayner, N.W.; Tachmazidou, I.; Klump, K.L.; Treasure, J. et al.
A genome-wide association study of anorexia nervosa // Molecular psychiatry, 19 (2014), 10; 1085-1094 doi:10.1038/mp.2013.187 (međunarodna recenzija, članak, znanstveni)
Boraska, V., Franklin, C., Floyd, J., Thornton, L., Huckins, L., Southam, L., Rayner, N., Tachmazidou, I., Klump, K. & Treasure, J. (2014) A genome-wide association study of anorexia nervosa. Molecular psychiatry, 19 (10), 1085-1094 doi:10.1038/mp.2013.187.
@article{article, author = {Boraska, Vesna and Franklin, C.S. and Floyd, J.A. and Thornton, L.M. and Huckins, L.M. and Southam, L. and Rayner, N.W. and Tachmazidou, I. and Klump, K.L. and Treasure, J. and Lewis, C.M. and Schmidt, U. and Tozzi, F. and Kiezebrink, K. and Hebebrand, J. and Gorwood, P. and Adan, R.A. and Kas, M.J. and Favaro, A. and Santonastaso, P. and Fern\'{a}ndez-Aranda, F. and Gratacos, M. and Rybakowski, F. and Dmitrzak-Weglarz, M. and Kaprio, J. and Keski-Rahkonen, A. and Raevuori, A. and Van Furth, E.F. and Slof-Op 't Landt, M.C. and Hudson, J.I. and Reichborn-Kjennerud, T. and Knudsen, G.P. and Monteleone, P. and Kaplan, A.S. and Karwautz, A. and Hakonarson, H. and Berrettini, W.H. and Guo, Y. and Li, D. and Schork, N.J. and Komaki, G. and Ando, T. and Inoko, H. and Esko, T. and Fischer, K. and M\"{a}nnik, K. and Metspalu, A. and Baker, J.H. and Cone, R.D. and Dackor, J. and DeSocio, J.E. and Hilliard, C.E. and O'Toole, J.K. and Pantel, J. and Szatkiewicz, J.P. and Taico, C. and Zerwas, S. and Trace, S.E. and Davis, O.S. and Helder, S. and B\"{u}hren, K. and Burghardt, R. and de Zwaan, M. and Egberts, K. and Ehrlich, S. and Herpertz-Dahlmann, B. and Herzog, W. and Imgart, H. and Scherag, A. and Scherag, S. and Zipfel, S. and Boni, C. and Ramoz, N. and Versini, A. and Brandys, M.K. and Danner, U.N. and de Kovel, C. and Hendriks, J. and Koeleman, B.P. and Ophoff, R.A. and Strengman, E. and van Elburg, A.A. and Bruson, A. and Clementi, M. and Degortes, D. and Forzan, M. and Tenconi, E. and Docampo, E. and Escaram\'{\i}s, G.. and Jim\'{e}nez-Murcia, S and Lissowska, J. and Rajewski, A. and Szeszenia-Dabrowska, N. and Slopien, A. and Hauser, J. and Karhunen, L. and Meulenbelt, I. and Slagboom, P.E. and Tortorella, A. and Maj, M. and Dedoussis, G. and Dikeos, D. and Gonidakis, F. and Tziouvas, K. and Tsitsika, A. and Papezova, H. and Slachtova, L. and Martaskova, D. and Kennedy, J.L. and Levitan, R.D. and Yilmaz, Z. and Huemer, J. and Koubek, D. and Merl, E. and Wagner, G. and Lichtenstein, P. and Breen, G. and Cohen-Woods, S. and Farmer, A. and McGuffin, P. and Cichon, S. and Giegling, I. and Herms, S. and Rujescu, D. and Schreiber, S. and Wichmann, H.E. and Dina, C. and Sladek, R. and Gambaro, G. and Soranzo, N. and Julia, A. and Marsal, S and Rabionet, R and Gaborieau, V and Dick, D.M. and Palotie, A. and Ripatti, S. and Wid\'{e}n, E. and Andreassen, OA and Espeseth, T and Lundervold, A and Reinvang, I. and Steen, V.M. and Le Hellard, S. and Mattingsdal, M. and Ntalla, I. and Bencko, V. and Foretova, L. and Janout, V. and Navratilova, M. and Gallinger, S. and Pinto, D. and Scherer, S.W. and Aschauer, H. and Carlberg, L. and Schosser, A. and Alfredsson, L. and Ding, B. and Klareskog, L. and Padyukov, L. and Courtet, P. and Guillaume, S. and Jaussent, I. and Finan, C. and Kalsi, G. and Roberts, M. and Logan, D.W. and Peltonen, L. and Ritchie, G.R. and Barrett, J.C. and Estivill, X and Hinney, A and Sullivan, PF and Collier, DA and Zeggini, E and Bulik, CM}, year = {2014}, pages = {1085-1094}, DOI = {10.1038/mp.2013.187}, keywords = {anorexia nervosa, body mass index, eating disorders, genome-wide association study, GWAS, metabolic}, journal = {Molecular psychiatry}, doi = {10.1038/mp.2013.187}, volume = {19}, number = {10}, issn = {1359-4184}, title = {A genome-wide association study of anorexia nervosa}, keyword = {anorexia nervosa, body mass index, eating disorders, genome-wide association study, GWAS, metabolic} }
@article{article, author = {Boraska, Vesna and Franklin, C.S. and Floyd, J.A. and Thornton, L.M. and Huckins, L.M. and Southam, L. and Rayner, N.W. and Tachmazidou, I. and Klump, K.L. and Treasure, J. and Lewis, C.M. and Schmidt, U. and Tozzi, F. and Kiezebrink, K. and Hebebrand, J. and Gorwood, P. and Adan, R.A. and Kas, M.J. and Favaro, A. and Santonastaso, P. and Fern\'{a}ndez-Aranda, F. and Gratacos, M. and Rybakowski, F. and Dmitrzak-Weglarz, M. and Kaprio, J. and Keski-Rahkonen, A. and Raevuori, A. and Van Furth, E.F. and Slof-Op 't Landt, M.C. and Hudson, J.I. and Reichborn-Kjennerud, T. and Knudsen, G.P. and Monteleone, P. and Kaplan, A.S. and Karwautz, A. and Hakonarson, H. and Berrettini, W.H. and Guo, Y. and Li, D. and Schork, N.J. and Komaki, G. and Ando, T. and Inoko, H. and Esko, T. and Fischer, K. and M\"{a}nnik, K. and Metspalu, A. and Baker, J.H. and Cone, R.D. and Dackor, J. and DeSocio, J.E. and Hilliard, C.E. and O'Toole, J.K. and Pantel, J. and Szatkiewicz, J.P. and Taico, C. and Zerwas, S. and Trace, S.E. and Davis, O.S. and Helder, S. and B\"{u}hren, K. and Burghardt, R. and de Zwaan, M. and Egberts, K. and Ehrlich, S. and Herpertz-Dahlmann, B. and Herzog, W. and Imgart, H. and Scherag, A. and Scherag, S. and Zipfel, S. and Boni, C. and Ramoz, N. and Versini, A. and Brandys, M.K. and Danner, U.N. and de Kovel, C. and Hendriks, J. and Koeleman, B.P. and Ophoff, R.A. and Strengman, E. and van Elburg, A.A. and Bruson, A. and Clementi, M. and Degortes, D. and Forzan, M. and Tenconi, E. and Docampo, E. and Escaram\'{\i}s, G.. and Jim\'{e}nez-Murcia, S and Lissowska, J. and Rajewski, A. and Szeszenia-Dabrowska, N. and Slopien, A. and Hauser, J. and Karhunen, L. and Meulenbelt, I. and Slagboom, P.E. and Tortorella, A. and Maj, M. and Dedoussis, G. and Dikeos, D. and Gonidakis, F. and Tziouvas, K. and Tsitsika, A. and Papezova, H. and Slachtova, L. and Martaskova, D. and Kennedy, J.L. and Levitan, R.D. and Yilmaz, Z. and Huemer, J. and Koubek, D. and Merl, E. and Wagner, G. and Lichtenstein, P. and Breen, G. and Cohen-Woods, S. and Farmer, A. and McGuffin, P. and Cichon, S. and Giegling, I. and Herms, S. and Rujescu, D. and Schreiber, S. and Wichmann, H.E. and Dina, C. and Sladek, R. and Gambaro, G. and Soranzo, N. and Julia, A. and Marsal, S and Rabionet, R and Gaborieau, V and Dick, D.M. and Palotie, A. and Ripatti, S. and Wid\'{e}n, E. and Andreassen, OA and Espeseth, T and Lundervold, A and Reinvang, I. and Steen, V.M. and Le Hellard, S. and Mattingsdal, M. and Ntalla, I. and Bencko, V. and Foretova, L. and Janout, V. and Navratilova, M. and Gallinger, S. and Pinto, D. and Scherer, S.W. and Aschauer, H. and Carlberg, L. and Schosser, A. and Alfredsson, L. and Ding, B. and Klareskog, L. and Padyukov, L. and Courtet, P. and Guillaume, S. and Jaussent, I. and Finan, C. and Kalsi, G. and Roberts, M. and Logan, D.W. and Peltonen, L. and Ritchie, G.R. and Barrett, J.C. and Estivill, X and Hinney, A and Sullivan, PF and Collier, DA and Zeggini, E and Bulik, CM}, year = {2014}, pages = {1085-1094}, DOI = {10.1038/mp.2013.187}, keywords = {anorexia nervosa, body mass index, eating disorders, genome-wide association study, GWAS, metabolic}, journal = {Molecular psychiatry}, doi = {10.1038/mp.2013.187}, volume = {19}, number = {10}, issn = {1359-4184}, title = {A genome-wide association study of anorexia nervosa}, keyword = {anorexia nervosa, body mass index, eating disorders, genome-wide association study, GWAS, metabolic} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

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