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Pregled bibliografske jedinice broj: 728015

Using ancestry-informative markers to identify fine structure across 15 populations of European origin.

Huckins, L.; Boraska, Vesna; Franklin, C.S.; Floyd, J.A.; Southam, L.; GCAN; WTCCC3; Sullivan, P.F.; Bulik, C.M.; Collier, D.A. et al.
Using ancestry-informative markers to identify fine structure across 15 populations of European origin. // European journal of human genetics, 22 (2014), 10; 1190-1200 doi:10.1038/ejhg.2014.1 (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 728015 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Using ancestry-informative markers to identify fine structure across 15 populations of European origin.

Autori
Huckins, L. ; Boraska, Vesna ; Franklin, C.S. ; Floyd, J.A. ; Southam, L. ; GCAN ; WTCCC3 ; Sullivan, P.F. ; Bulik, C.M. ; Collier, D.A. ; Tyler-Smith, C. ; Zeggini, E. ; Tachmazidou, I.

Izvornik
European journal of human genetics (1018-4813) 22 (2014), 10; 1190-1200

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
population stratification; AIMs; principal component analysis

Sažetak
The Wellcome Trust Case Control Consortium 3 anorexia nervosa genome-wide association scan includes 2907 cases from 15 different populations of European origin genotyped on the Illumina 670K chip. We compared methods for identifying population stratification, and suggest list of markers that may help to counter this problem. It is usual to identify population structure in such studies using only common variants with minor allele frequency (MAF) 45% ; we find that this may result in highly informative SNPs being discarded, and suggest that instead all SNPs with MAF 41% may be used. We established informative axes of variation identified via principal component analysis and highlight important features of the genetic structure of diverse European-descent populations, some studied for the first time at this scale. Finally, we investigated the substructure within each of these 15 populations and identified SNPs that help capture hidden stratification. This work can provide information regarding the designing and interpretation of association results in the International Consortia.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Temeljne medicinske znanosti

Napomena
Rad je kao predavanje prezentiran na skupu European Society of Human Genetics Congress, održanom u Nürnberg, Njemačka, od 23.-26.06.2012.g. ; uz međunarodnu recenziju objavljen kao sazetak u navedenom časopisu ; GCAN = Genetics Consortium of Anorexia Nervosa ; WTCCC3 = Wellcome Trust Case Control Consortium 3.



POVEZANOST RADA

Projekti:
HRZZ-PD-02.03/68 - Analiza i interpretacija cjelogenomskih studija povezanosti: primjena u projektu 10,001 Dalmatinac

Ustanove:
Medicinski fakultet, Split

Profili:

Avatar Url Vesna Boraska Perica (autor)

Poveznice na cjeloviti tekst rada:

Pristup cjelovitom tekstu rada doi www.ncbi.nlm.nih.gov www.nature.com

Citiraj ovu publikaciju:

Huckins, L.; Boraska, Vesna; Franklin, C.S.; Floyd, J.A.; Southam, L.; GCAN; WTCCC3; Sullivan, P.F.; Bulik, C.M.; Collier, D.A. et al.
Using ancestry-informative markers to identify fine structure across 15 populations of European origin. // European journal of human genetics, 22 (2014), 10; 1190-1200 doi:10.1038/ejhg.2014.1 (međunarodna recenzija, članak, znanstveni)
Huckins, L., Boraska, V., Franklin, C., Floyd, J., Southam, L., GCAN, WTCCC3, Sullivan, P., Bulik, C. & Collier, D. (2014) Using ancestry-informative markers to identify fine structure across 15 populations of European origin.. European journal of human genetics, 22 (10), 1190-1200 doi:10.1038/ejhg.2014.1.
@article{article, author = {Huckins, L. and Boraska, Vesna and Franklin, C.S. and Floyd, J.A. and Southam, L. and Sullivan, P.F. and Bulik, C.M. and Collier, D.A. and Tyler-Smith, C. and Zeggini, E. and Tachmazidou, I.}, year = {2014}, pages = {1190-1200}, DOI = {10.1038/ejhg.2014.1}, keywords = {population stratification, AIMs, principal component analysis}, journal = {European journal of human genetics}, doi = {10.1038/ejhg.2014.1}, volume = {22}, number = {10}, issn = {1018-4813}, title = {Using ancestry-informative markers to identify fine structure across 15 populations of European origin.}, keyword = {population stratification, AIMs, principal component analysis} }
@article{article, author = {Huckins, L. and Boraska, Vesna and Franklin, C.S. and Floyd, J.A. and Southam, L. and Sullivan, P.F. and Bulik, C.M. and Collier, D.A. and Tyler-Smith, C. and Zeggini, E. and Tachmazidou, I.}, year = {2014}, pages = {1190-1200}, DOI = {10.1038/ejhg.2014.1}, keywords = {population stratification, AIMs, principal component analysis}, journal = {European journal of human genetics}, doi = {10.1038/ejhg.2014.1}, volume = {22}, number = {10}, issn = {1018-4813}, title = {Using ancestry-informative markers to identify fine structure across 15 populations of European origin.}, keyword = {population stratification, AIMs, principal component analysis} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

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