Naslov
An adjustable mandibular advancement device for the treatment of obstructive sleep apnea syndrome and its implications on glucose metabolism: a prospective 1-year follow-up study

Autori
Galić, Tea ; Božić, Joško ; Galić, Ivan ; Ivković, Natalija ; Mihanović, Frane ; Tičinović Kurir, Tina ; Đogas, Zoran

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Journal of Sleep Research / Derk-Jan Dijk - : European Sleep Research Society, 2014, 204-204

Skup
22nd Congress of the European Sleep Research Society

Mjesto i datum
Talin, Estonija, 16.09.2014. - 20.09.2014

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Obstructive sleep apnea syndrome (OSAS) ; mandibular advancement device (MAD) ; apnea-hypopnea index (AHI)

Sažetak
OBJECTIVES: Obstructive sleep apnea syndrome (OSAS) is recognized as an independent risk factor for insulin resistance, glucose intolerance and type 2 diabetes. The aim of this study was to determine the efficacy of the custom-made adjustable mandibular advancement device (MAD) after 1 year of treatment and its implications on the glucose metabolism. METHODS: A total of 15 patients with mild to moderate OSAS were treated with custom-made adjustable MAD and they were followed-up after 1 year of treatment. Sleep studies in the sleep clinic were performed with and without the MAD and fasting blood samples were obtained at baseline and at the time of follow-up. RESULTS: The mean apnea-hypopnea index (AHI) decreased significantly from 22.9±5.9 at baseline to 9.75±4.63 after 1 year of treatment (P<0.001), measured with the same polysomnography device. Fasting plasma glucose values (5.26±0.52 to 4.89±0.51 mmol/L, P<0.001) and fasting plasma insulin values (65.17±58.38 to 98.12±62.97 µU/ml, P=0.022) decreased significantly after 1 year of MAD treatment. There were no significant changes in the plasma glucose and insulin values after 120 minutes of oral glucose tolerance test (P>0.05). CONCLUSIONS: Our results indicate that the tested MAD was effective in reducing symptoms in mild to moderate OSAS patients by decreasing AHI and significantly decreasing fasting plasma glucose and insulin values.

Izvorni jezik
Engleski

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