Naslov
Pro-atrial natriuretic peptide hormone from right atria is correlated with cardiac depression in septic patients

Autori
Mazul-Sunko, Branka ; Žarković, Neven ; Vrkić, Nada ; Klinger, Rainer ; Perić, Mladen ; Bekavac-Bešlin, Miroslav ; Novskoski, M. ; Krizmanić, Attilio ; Gvozdenović, A. ; Topić, Elizabeta

Izvornik
Journal of endocrinological investigation (0391-4097) 24 (2001), 7; RC22-RC24

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
ProANP (I-98) ; plasma ; intensive care ; sepsis ; cardiac depression ; ARDS

Sažetak
N-terminal pro-atrial natriuretic peptide (ProANP (I-98))has been extensively investigated in patients wirh chronic heart failure and ischemic heart disease. It is found to be a better marker of cardiac dysfunction than atrial natriuretic peptide (ANP). The possible involvement of ProANP(I-98) in cardiac depression caused by sepsis has not been studied yet. Therefore, we analyzed atrial plasma concentration of ProANP(I-98)in 17 septic patients with hemodynamic variables measured or calculated using pulmonary artery catheter. The results of altogether measurements show a significant negative correlation of ProANP(I-98)and cardiac index (p<0.024), oxygen delivery (p<0.03) and oxygen consumption (p<0.03). There is also a positive correlation with pulmonary vascular resistance (p<0.03). ProANP(I-98) is significantly higher in patients who developed acute respiratory distress syndrome (ARDS) (p<0.001). This study implies that proANP(I-98) is a possible novel hormone marker od cardiac depression caused by sepsis that could be used for prediction od ARDS.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti

POVEZANOST RADA