Naslov
Učinkovitost primjene 0.3%-tne otopine pefloksacina u liječenju akutne difuzne upale zvukovoda
(Efficacy of administration of 0.3% pefloxacin solution in the treatment of acute diffuse inflammation of the auditory canal)

Autori
Kovačić, Mario ; Dželalija, Boris

Izvornik
Liječnički vjesnik : glasilo Hrvatskoga liječničkog zbora (0024-3477) 124 (2002); 199-202

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
otitis externa-mikrobiologija; farmakoterapija; pefloksacin-doziranje; terapijska upotreba
(otitis externa-microbiology; drug therapy; pefloxacin-administration and dosage; therapeutic use)

Sažetak
Acute diffuse inflammation of the auditory canal skin is most often caused by gram-negative organisms. Bacteriological analysis of swabs of the auditory canal skin in 70 patients with acute inflammation most frequently found P. aeruginosa, in 64% of patients. Administration of 0.3% pefloxacin solution in the treatment of acute diffuse inflammation of the auditory canal achieved statistically significant therapeutic success in the first five days of treatment, compared to the efficacy of locally applied aminoglykoside pharmaceutical products. Therapeutic success of 10-day local administration of 0.3% pefloxacine solution in 35 investigated patients, estimated by clinical examination, resulted in complete cure in all examinees, while in those treated with standard aminoglycoside drops therapeutic success was registered in 74% of patients. Two properties, low pH and antimicrobial efficacy, primarily on P. aeruginosa, make 0.3% pefloxacin solution an effective drug in the local treatment of acute diffuse inflammation of the auditory canal.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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