Naslov
Three players with the same goal: hydrogen peroxide, nitric oxide and hydrogen sulfide as part of the same team

Autori
Hancock, John T. ; Whiteman, Matthew ; Wood, Mark E. ; Wilson, Ian D. ; Ladomery, Michael R. ; Williams, Eleanor ; Teklić, Tihana ; Lisjak, Miroslav

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Abstracts of the Third International Congress of Respiratory Science / Markus Lambertz, Kristina Grommes, Steven F. Perry - Hildesheim : Franzbecker, 2014, 24-25

ISBN
978-3-88120-924-3

Skup
Third International Congress of Respiratory Science

Mjesto i datum
Bad Honnef, Njemačka, 06.07.2014. - 10.07.2014

Vrsta sudjelovanja
Plenarno

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Hydrogen sulfide ; Nitric oxide ; Hydrogen peroxide ; Reactive oxygen species

Sažetak
For many years it has been recognised that reactive molecules are involved in the process of cell signalling in a wide range of organisms, including animals and plants. It is known that oxidative stress and the redox status of cells is instrumental in control of many processes, including development and apoptosis [1]. Such mechanisms are influenced by the generation of reactive oxygen species (ROS) such as hydrogen peroxide and superoxide, but are also influenced by the levels of antioxidants such as superoxide dismutase, catalase, ascorbate, glutathione and vitamin E. Cellular control is also under the influence of reactive nitrogen species, such as nitric oxide (NO) [2]. More recently another reactive compound has been added to this list, that is, hydrogen sulfide (H2S) [3, 4]. Dedicated enzymes, such as NADPH oxidases, nitrate reductase and desulfhydrases have been found which generate such compounds, and mechanisms are present in cells to ensure that these compounds are removed when no longer needed. In the main they are freely diffusible in biological systems and therefore even though ROS, NO and H2S are all relatively reactive they can partake in the control of cellular events. Numerous proteins such as kinases, phosphatases and transcription factors have been found to have their activity altered by these compounds. However, when looking at both the mechanisms involving ROS, NO and H2S, and the physiological responses which are influenced by them, a large overlap is seen. Often stress responses are seen to involve these chemicals, with such stresses including heat, cold, pathogens, salt and heavy metals. Therefore it would be proposed that there would need to be an interaction between these compounds, but such interactions are far from being clearly defined. It is known that direct reactions between ROS, NO and H2S can yield compounds such as peroxynitrite and nitrosothiols, which themselves may have signalling effects. Furthermore ROS and NO can react with thiol groups in proteins, by mechanisms of oxidation and S-nitrosation. Recently it has been reported that H2S can also react with thiols, in a process which appears to be unique to H2S and related species, called sulfhydration, so it is likely that such groups are a point of interaction of signalling involving these reactive compounds, but it may be that they are in competition with each other, with different outcomes. Recently it has been found that H2S can alleviate the onset of disease symptoms in animals, for example atherosclerosis, while in plants it has been found to prolong the storage of fruit post- harvest, with influences on antioxidants being a proposed mechanism. Therefore it is important to understand how H2S influences cellular events and a holistic view is needed when considering these compounds and how they interact together and fit into the large scheme of signalling in cells [4]. Only by looking at their potential reactions and influences together will a realistic understanding of how reactive compounds work in unison to bring about the control of cells be achieved.

Izvorni jezik
Engleski

Znanstvena područja
Biologija

POVEZANOST RADA