Pregled bibliografske jedinice broj: 727337
Cardiac mitochondrial ATP-sensitive potassium channel is activated by nitric oxide in vitro
Cardiac mitochondrial ATP-sensitive potassium channel is activated by nitric oxide in vitro // FEBS letters, 581 (2007), 22; 4255-4259 doi:10.1016/j.febslet.2007.07.071 (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 727337 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Cardiac mitochondrial ATP-sensitive potassium
channel is activated by nitric oxide in vitro
Autori
Ljubković, Marko ; Shi, Yang ; Cheng, Quinli ; Bošnjak, Željko ; Jiang, Ming Tao
Izvornik
FEBS letters (0014-5793) 581
(2007), 22;
4255-4259
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
heart ; mitochondria ; preconditioning ; free radical ; glibenclamide ; KATP
Sažetak
Previous observations on the activation of the mitochondrial ATP-sensitive potassium channel (mitoKATP) by nitric oxide (NO) in myocardial preconditioning were based on indirect evidence. In this study, we have investigated the direct effect of NO on the rat cardiac mitoKATP after reconstitution of the inner mitochondrial membranes into lipid bilayers. We found that the mitoKATP was activated by exogenous NO donor S- nitroso-N- acetyl penicillamine or PAPA NONOate. This activation was inhibited by mitoKATP blockers 5-hydroxydecanoate or glibenclamide. Our observations confirm that NO can directly activate the cardiac mitoKATP, which may underlie its contribution to myocardial preconditioning.
Izvorni jezik
Engleski
Znanstvena područja
Temeljne medicinske znanosti
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE
