Naslov
Genome-wide association analysis of incident coronary heart disease (CHD) in African Americans : a short report

Autori
Barbalić, Maja ; Reiner, Alex P. ; Wu, Chunyuan ; Hixson, James E. ; Franceschini, Nora ; Eaton, Charles B. ; Heiss, Gerardo ; Couper, David ; Mosley, Thomas ; Boerwinkle, Eric

Izvornik
PLOS genetics (1553-7390) 7 (2011), 8; E1002199, 5

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, kratko priopcenje, znanstveni

Ključne riječi
genome-wide association ; coronary heart disease ; African Americans

Sažetak
African Americans have the highest rate of mortality due to coronary heart disease (CHD). Although multiple loci have been identified influencing CHD risk in European-Americans using a genome-wide association (GWAS) approach, no GWAS of incident CHD has been reported for African Americans. We performed a GWAS for incident CHD events collected during 19 years of follow-up in 2, 905 African Americans from the Atherosclerosis Risk in Communities (ARIC) study. We identified a genome-wide significant SNP (rs1859023, MAF = 31%) located at 7q21 near the PFTK1 gene (HR = 0.57, 95% CI 0.46 to 0.69, p = 1.86×10−08), which replicated in an independent sample of over 8, 000 African American women from the Women's Health Initiative (WHI) (HR = 0.81, 95% CI 0.70 to 0.93, p = 0.005). PFTK1 encodes a serine/threonine-protein kinase, PFTAIRE-1, that acts as a cyclin-dependent kinase regulating cell cycle progression and cell proliferation. This is the first finding of incident CHD locus identified by GWAS in African Americans.

Izvorni jezik
Engleski

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