Naslov
Efficiency of imidazolium and quinuclidinium derivatives combined with HI-6 or diazepam in soman an tabun poisoning

Autori
Radić, Božica, Lucić, Ana ; Peraica, Maja ; Domijan, Ana-Marija ; Bradamante, Vlasta

Izvornik
Acta pharmaceutica (1330-0075) 51 (2001), 1; 1-9

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
acethylcholinesterase; antidotes; oximes; imidazolium; quinuclidinium; soman; tabun

Sažetak
This paper describes a test of antidotal efficiency of newly synthesized compounds (I-VIII) which contain only imidazolium, only quinuclidinium, or both, and bis-imidazolium rings with various substituents (oxo, hydroxy, carbamoyl, and phenyl), on mice poisoned with soman or tabun. The results were expressed as therapeutic factor (TF), therapeutic dose (TD), and the ratio between dead and injected animals. Imidazolium-quinuclidinium compounds which contain oxo (III and IV) or carbamoyl group (compounds V and VI) and bis-imidazolium compound with phenyl groups (VIII) were more effective than hydroxy (I and II) and mono-imidazolium (VII) derivatives tested in soman poisoning. The therapeutic effect was better in soman than in tabun poisoning. The best therapeutic effect was obtained with compounds VI and VIII which were further tested in combination with HI-6 and/or diazepam. Compounds VI or VIII combined with HI-6 had a very good therapeutic effect, but they were not that efficient in combination with diazepam. Compound VI, the most efficient oxime in previous experiments, and HI-6 were tested in pretreatment and therapy of soman poisoning. HI-6 showed higher efficiency in pretreatment which was not time-dependent. Compound VI was more efficient in the therapy than HI-6 and the antidotal effect of both compounds was better when they were applied immediately after soman poisoning. Combined pretreatment and therapy, within 10 min (before and after poisoning), yielded better results than pretreatment or therapy alone.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA