Naslov
Postnatal Changes In The Ratio Of Human Brain Volume To Endocranial Volume

Autori
Galkowski, Valentina ; Raguž, Marina ; Mandić, Dora ; Radoš, Milan ; Judaš, Miloš

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, ostalo, ostalo

Izvornik
8th Fens Forum of Neuroscience Book of Abstracts. / - , 2012

Skup
8th FENS Forum of Neuroscience

Mjesto i datum
Barcelona, Španjolska, 14.07.2012. - 18.07.2012

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
MR volumetry ; brain development ; cerebrospinal fluid ; endocranial volume

Sažetak
The ratio of human brain volume (BV) to endocranial volume (EV) is changing during the life time. Previous studies showed that BV/EV ratio decreases with age with consequent increase of the cerebrospinal fluid volume (CVV). In this study we analyzed endocranial volume (EV), brain tissue volume (BV) and cerebrospinal fluid volume (CVV) of 42 individuals divided into 5 age groups (group 1 = 0 - 1 year, group 2 = 1 - 3 years, group 3 = 3 - 6 years, group 4 = 20 - 30 years and group 5 = 50 - 60 years). Male and females were equally represented in all groups. All subjects had normal brain morphology and normal pattern of the brain development. Significant change in the BV/EV ratio and CVV/BV ratio was observed during the first three years of life.This is also the period of the fastest increase of BV and EV while CVV is increasing slower thus explaining rapid changes of these ratios After the third year of life BV/EV and CVV/EV volumes reach the plateau with all three volumes increasing at the steady rate. Significant change of these volumes can be observed again in the group 5. All three volumes change significantly during first three years of life reaching almost adult values at the end of the third year of life. The knowledge of BV/EV ratio as well as CVV/EV ratio at different postnatal ages is important not only for clinical studies, but also for comparative life-history studies of postnatal brain development in humans and great apes.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA