Naslov
The X value in the craniofacial equation: X chromosome effects on oral and craniofacial development

Autori
Dumančić, Jelena

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Programme and book of abstracts of the 16th International Symposium on Dental Morphology and 1st Congress of the International Association for Paleodontology, August, 26 – 30, 2014, Zagreb, Croatia. U: Bulletin of the International Association for Paleodontology. 2014 ; 8(1) / Vodanović, Marin - Zagreb, 2014, 90-90

Skup
Programme and book of abstracts of the 16th International Symposium on Dental Morphology and 1st Congress of the International Association for Paleodontology

Mjesto i datum
Zagreb, Hrvatska, 26.08.2014. - 30.08.2014

Vrsta sudjelovanja
Poster

Vrsta recenzije
Podatak o recenziji nije dostupan

Ključne riječi
X chromosome ; gonadal dysgenesis ; craniofacial development
(X chromosome ; craniofacial development ; Turner syndrome ; Klinefelter syndrome)

Sažetak
The investigation of the X chromosome influence on oral and craniofacial development was the main goal of the research project "Characteristics of the Craniofacial Complex in Gonadal Dysgenesis, " conducted at the Department of Dental Anthropology, Zagreb University School of Dental Medicine. This lecture covers project findings combined with those from other relevant studies in the field. Growth and development are simultaneous biological processes leading from an undifferentiated and immature state to the highly organized and specialized state of a mature human. Although development lasts for about two decades, allowing much time for environmental factors to act, it is under strong genetic control. While autosomes are responsible for somatic growth, sex chromosomes are primarily responsible for sex determination. However, studies in individuals with sex chromosome anomalies show that they also influence somatic growth in general and the craniofacial region in particular. Structural aberrations or complete absence of one of the X chromosomes in phenotypic females results in Turner syndrome, while excess X chromosomes in phenotypic males are associated with Klinefelter syndrome. The opposite effects of X gene dosage are exerted in dental development, including tooth crown and root dimensions and morphology, tooth number and eruption. Occlusal patterns include distal molar occlusion, with lateral crossbite and anterior open bite in Turner syndrome and mesial molar occlusion in Klinefelter syndrome. Cephalometric craniofacial morphology is characterized by reduced mandibular dimensions and larger cranial base angle in Turner syndrome while individuals with Klinefelter syndrome show the opposite, with larger mandibles and more acute cranial base angles. Genes on the X chromosome have a significant influence on oral and craniofacial growth, including dental development and growth of the maxilla, mandible and cranial base. The goal of future molecular studies is to identify the loci of the responsible X chromosome genes.

Izvorni jezik
Engleski

Znanstvena područja
Dentalna medicina

POVEZANOST RADA