Naslov
Health-related quality of life in systemic sclerosis as measured by the short form 36 : relationship with clinical and biological markers

Autori
Del Rosso, Angela ; Boldrini, Maura ; D'Agostino, David ; Plinio, G. ; Placidi, A. ; Scarpato, A. ; Pignone, A. ; Generini, S. ; Konttinen, Y. ; Zoppi, M. ; Vlak, Tonko ; Placidi, G. ; Matucci-Cerinic M.

Izvornik
Arthritis and rheumatism (0004-3591) 51 (2004), 3; 475-481

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Systemic sclerosis; SF-36; Health-related quality of life; Coping

Sažetak
Objective was to evaluate health-related quality of life (HRQOL) in patients with systemic sclerosis (SSc) using the Short Form 36 (SF-36) and to correlate SF-36 scores with clinical and biologic markers. The SF-36 was administered to 24 controls and 24 SSc patients. SSc patients also were evaluated for subset (limited SSc [lSSc] and diffuse SSc [dSSc]), age, disease duration, angiotensin- converting enzyme (ACE) levels, autoantibodies, and skin and internal organ involvement. The physical summary score (PSS) was lower in SSc patients than in controls (P < 0.05), whereas the mental summary score (MSS) was higher in dSSc than in lSSc patients (P < 0.05). Five of 8 single SF-36 domain scores were lower in SSc patients than in controls (P < 0.05). Vitality was higher in dSSc than in controls (P < 0.001). In SSc, elder age correlated with lower PSS ; low ACE levels and high skin score correlated with higher general mental health and role limitations due to physical problems, respectively (P < 0.05). Patients with heart involvement had higher scores in general health perceptions (P < 0.05). The SF-36 shows that HRQOL is impaired in patients with SSc. Higher scores in MSS and vitality in patients with dSSc and correlations of high SF-36 scores with specific organ involvement suggest that SSc patients with severe disease are more able to cope with HRQOL modification.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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