Pregled bibliografske jedinice broj: 725289
3-hydroxy-3-methylglutaryl-CoA-like synthases direct the formation of methyl and ethyl side groups in the biosynthesis of the antibiotic myxovirescin A.
3-hydroxy-3-methylglutaryl-CoA-like synthases direct the formation of methyl and ethyl side groups in the biosynthesis of the antibiotic myxovirescin A. // ChemBioChem, 8 (2007), 5; 497-500 doi:10.1002/cbic.200700017 (međunarodna recenzija, pismo, znanstveni)
CROSBI ID: 725289 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
3-hydroxy-3-methylglutaryl-CoA-like synthases direct the formation of methyl and ethyl side groups in the biosynthesis of the antibiotic myxovirescin A.
Autori
Simunović, Vesna ; Müller, R.
Izvornik
ChemBioChem (1439-4227) 8
(2007), 5;
497-500
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pismo, znanstveni
Ključne riječi
polyketides; synthases; antibiotics; methylation; Myxococcus xanthuspolyketides; synthases
Sažetak
Thumbnail image of graphical abstract Deletion oftaF, a homologue of 3-hydroxy-3-methylglutaryl-CoA synthase (HMGS), causes a switch in the myxovirescin programming algorithm and leads to the production of a novel myxovirescin analogue with a shorter side chain. These results provide the first in vivo evidence for the role of HMGS-like enzymes in the incorporation of both acetate- and propionate-derived units into polyketide scaffolds.
Izvorni jezik
Engleski
Znanstvena područja
Kemija
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE
