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Pregled bibliografske jedinice broj: 725236

Flavonoid diosmetin increases ATP levels in kidney cells and relieves ATP depleting effect of ochratoxin A

Poór, Miklós; Veres, Balázs; Jakus, Péter B.; Antus, Csenge; Montskó, Gergely; Zrínyi, Zita, Vladimir-Knežević, Sanda; Petrik, József; Kőszegi, Tamás
Flavonoid diosmetin increases ATP levels in kidney cells and relieves ATP depleting effect of ochratoxin A // Journal of photochemistry and photobiology. B, Biology, 132 (2014), 1-9 doi:10.1016/j.jphotobiol.2014.01.016 (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 725236 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Flavonoid diosmetin increases ATP levels in kidney cells and relieves ATP depleting effect of ochratoxin A

Autori
Poór, Miklós ; Veres, Balázs ; Jakus, Péter B. ; Antus, Csenge ; Montskó, Gergely ; Zrínyi, Zita, Vladimir-Knežević, Sanda ; Petrik, József ; Kőszegi, Tamás

Izvornik
Journal of photochemistry and photobiology. B, Biology (1011-1344) 132 (2014); 1-9

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
diosmetin; ATP; flavonoids; ochratoxin A; kidney cells

Sažetak
Diosmetin (DIOS) is a flavone aglycone commonly occurring in citrus species and olive leaves, in addition it is one of the active ingredients of some medications. Based on both in vitro and in vivo studies several beneficial effects are attributed to DIOS but the biochemical background of its action seems to be complex and it has not been completely explored yet. Previous investigations suggest that most of the flavonoid aglycones have negative effect on ATP synthesis in a dose dependent manner. In our study 17 flavonoids were tested and interestingly DIOS caused a significant elevation of intracellular ATP levels after 6- and 12-h incubation in MDCK kidney cells. In order to understand the mechanism of action, intracellular ATP and protein levels, ATP/ADP ratio, cell viability and ROS levels were determined after DIOS treatment. In addition, impacts of different enzyme inhibitors and effect of DIOS on isolated rat liver mitochondria were also tested. Finally, the influence of DIOS on the ATP depleting effect of the mycotoxin, ochratoxin A was also investigated. Our major conclusions are the followings: DIOS increases intracellular ATP levels both in kidney and in liver cells. Inhibition of glycolysis or citric acid cycle does not decrease the observed effect. DIOS-induced elevation of ATP levels is completely abolished by the inhibition of ATP synthase. DIOS is able to completely reverse the ATP-depleting effect of the mycotoxin, ochratoxin A. Most probably the DIOS- induced impact on ATP system does not originate from the antioxidant property of DIOS. Based on our findings DIOS may be promising agent to positively influence ATP depletion caused by some metabolic poisons.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Farmacija



POVEZANOST RADA

Projekti:
006-0061117-1238 - Bioaktivne prirodne tvari: izolacija, karakterizacija i biološki učinci (Vladimir-Knežević, Sanda, MZOS ) ( CroRIS)
006-1340227-1248 - Endotelinski sustav i antioksidansi u zloćudnim tumorima (Petrik, Jozsef, MZOS ) ( CroRIS)

Ustanove:
Farmaceutsko-biokemijski fakultet, Zagreb

Profili:

Avatar Url Jozsef Petrik (autor)

Avatar Url Sanda Vladimir-Knežević (autor)

Poveznice na cjeloviti tekst rada:

doi www.sciencedirect.com

Citiraj ovu publikaciju:

Poór, Miklós; Veres, Balázs; Jakus, Péter B.; Antus, Csenge; Montskó, Gergely; Zrínyi, Zita, Vladimir-Knežević, Sanda; Petrik, József; Kőszegi, Tamás
Flavonoid diosmetin increases ATP levels in kidney cells and relieves ATP depleting effect of ochratoxin A // Journal of photochemistry and photobiology. B, Biology, 132 (2014), 1-9 doi:10.1016/j.jphotobiol.2014.01.016 (međunarodna recenzija, članak, znanstveni)
Poór, M., Veres, B., Jakus, P., Antus, C., Montskó, G., Zrínyi, Zita, Vladimir-Knežević, Sanda, Petrik, J. & Kőszegi, T. (2014) Flavonoid diosmetin increases ATP levels in kidney cells and relieves ATP depleting effect of ochratoxin A. Journal of photochemistry and photobiology. B, Biology, 132, 1-9 doi:10.1016/j.jphotobiol.2014.01.016.
@article{article, author = {Po\'{o}r, Mikl\'{o}s and Veres, Bal\'{a}zs and Jakus, P\'{e}ter B. and Antus, Csenge and Montsk\'{o}, Gergely and Petrik, J\'{o}zsef and K\H{o}szegi, Tam\'{a}s}, year = {2014}, pages = {1-9}, DOI = {10.1016/j.jphotobiol.2014.01.016}, keywords = {diosmetin, ATP, flavonoids, ochratoxin A, kidney cells}, journal = {Journal of photochemistry and photobiology. B, Biology}, doi = {10.1016/j.jphotobiol.2014.01.016}, volume = {132}, issn = {1011-1344}, title = {Flavonoid diosmetin increases ATP levels in kidney cells and relieves ATP depleting effect of ochratoxin A}, keyword = {diosmetin, ATP, flavonoids, ochratoxin A, kidney cells} }
@article{article, author = {Po\'{o}r, Mikl\'{o}s and Veres, Bal\'{a}zs and Jakus, P\'{e}ter B. and Antus, Csenge and Montsk\'{o}, Gergely and Petrik, J\'{o}zsef and K\H{o}szegi, Tam\'{a}s}, year = {2014}, pages = {1-9}, DOI = {10.1016/j.jphotobiol.2014.01.016}, keywords = {diosmetin, ATP, flavonoids, ochratoxin A, kidney cells}, journal = {Journal of photochemistry and photobiology. B, Biology}, doi = {10.1016/j.jphotobiol.2014.01.016}, volume = {132}, issn = {1011-1344}, title = {Flavonoid diosmetin increases ATP levels in kidney cells and relieves ATP depleting effect of ochratoxin A}, keyword = {diosmetin, ATP, flavonoids, ochratoxin A, kidney cells} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

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