Long-term therapy with proton pump inhibitors is associated with decreased bone density

Bratanić, Andre; Kokić, Slaven; Hozo, Izet; Barišić, Igor; Kokić, Višnja

doi:10.1016/j.mehy.2009.01.003

Pregled bibliografske jedinice broj: 724794

Long-term therapy with proton pump inhibitors is associated with decreased bone density

Bratanić, Andre; Kokić, Slaven; Hozo, Izet; Barišić, Igor; Kokić, Višnja

Long-term therapy with proton pump inhibitors is associated with decreased bone density // Medical hypotheses, 72 (2009), 5; 608-609 doi:10.1016/j.mehy.2009.01.003 (podatak o recenziji nije dostupan, pismo, stručni)

CROSBI ID: 724794 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Long-term therapy with proton pump inhibitors is associated with decreased bone density

Autori
Bratanić, Andre ; Kokić, Slaven ; Hozo, Izet ; Barišić, Igor ; Kokić, Višnja

Izvornik
Medical hypotheses (0306-9877) 72 (2009), 5; 608-609

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pismo, stručni

Ključne riječi
Long therm therapy; proton pump inhibitors; bone density

Sažetak
It is well known that bone density is determined by the interrelationship of many factors in the human organism. A number of these factors act on general level (parathyreoid hormone, thyreoid hormones, growth hormone, sex hormones, and vitamin D). There are also various other factors (prostaglandines, interleukines, and growth factors) which act on local level. All of these factors influence bone density by stimulating or inhibiting the bone remodeling process. This process is regulated through the osteoprotegerin molecule (OPG-RANKL system), which activates osteoclasts. It was reported that bone turnover is decreased in patients treated with PPI. We hypothesized that long-term therapy is associated with decreased bone density, consequently with osteoporosis and fractures

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA

Ustanove:
KBC Split,
Medicinski fakultet, Split

Profili:

Izet Hozo (autor)