Naslov
REGULATION OF MITOPHAGY RECEPTORS BY PHOSPHORYLATION

Autori
Novak, Ivana ; Fischkin, Evgeni ; Marinković, Mija ; Hamacher-Brady, Anne ; Brady Nathan ; Đikić, Ivan

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Skup
PTMs in Cell Signaling

Mjesto i datum
Kopenhagen, Danska, 02.12.2012. - 05.12.2012

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
mitophagy ; autophagy ; mitochondria

Sažetak
Recent discoveries of autophagic receptors that recognize specific cellular cargo have opened a new chapter in autophagy field. Selective removal of damaged organelles or protein aggregates is essential for the proper cellular homeostasis and survival. We have recently identified and characterized Nix/Bnip3L mitochondrial protein as mitophagy receptor that, in LIR-dependent manner, interacts with LC3/GABARAP proteins and recruits autophagy machinery to damaged mitochondria. Moreover, we have shown that Nix mediates mitochondrial clearance during reticulocyte differentiation. Recent discovery of Optn, an autophagy receptor involved in recognition of intracellular bacteria, showed that its autophagic function is regulated by phosphorylation of the LIR motif. We are investigating the phosphorylation status of Nix and its homolog Bnip3 in regulation of mitophagy. Our preliminary results indicate that phosphorylation of mitophagy receptors Nix and Bnip3 is involved in fine tuning of mitophagy.

Izvorni jezik
Engleski

Znanstvena područja
Biologija

POVEZANOST RADA