Naslov
THE ROLE OF AUTOPHAGY RECEPTORS IN SELECTIVE REMOVAL OF MITOCHONDRIA

Autori
Marinković, Mija ; Terzić, Janoš ; Hamacher-Brady, Anne ; Brady, Nathan ; Dikic, Ivan ; Novak, Ivana

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
HDBMB2014 „The Interplay of Biomolecules“ / Maja Katalinić and Zrinka Kovarik - Zagreb : Hrvatsko Društvo za Biotehnologiju, 2014, 39-39

ISBN
978-953-95551-5-1

Skup
Congress of the Croatian Society of Biochemistry and Molecular Biology “The Interplay of Biomolecules”, HDBMB2014

Mjesto i datum
Zadar, Hrvatska, 24.09.2014. - 27.09.2014

Vrsta sudjelovanja
Pozvano predavanje

Vrsta recenzije
Nije recenziran

Ključne riječi
mitophagy ; autophagy ; mitochondria

Sažetak
Recent discoveries of autophagic receptors that recognize specific cellular cargo have opened a new chapter in autophagy field. Selective removal of damaged organelles or protein aggregates is essential for the proper cellular homeostasis and survival. We have recently identified and characterized Nix/Bnip3L mitochondrial protein as mitophagy receptor that, in LIR - dependent manner, interacts with LC3/GABARAP proteins and recruits autophagy machinery to damaged mitochondria. Moreover, we have shown that Nix mediates mitochondrial clearance during reticulocyte differentiation. Additionally, Nix forms strong homodimers and we propose that Nix dimerization is required for the recruitment of LC3/GABARAP to damaged mitochondria and is a trigger for mitophagy. Recent discovery of Optn, an autophagy receptor involved in recognition of intracellular bacteria, showed that its autophagic function is regulated by phosphorylation of the LIR motif. We are investigating the phosphorylation status of Nix and its homolog Bnip3 in regulation of mitophagy. Our preliminary results indicate that phosphorylation of mitophagy receptors Nix and Bnip3 is involved in fine tuning of mitophagy.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Temeljne medicinske znanosti

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