Naslov
Lipase Catalyzed Stereoselective Acylation of Ferrocene Aliphatic and Aromatic Diols

Autori
Đaković, Senka ; Rapić, Vladimir

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
8th European Symposium on Organic Reactivity / Eckert-Maksić, Mirjana; Glasovac, Zoran; Zrinski, Irena - Zagreb : Institut Ruđer Bošković, Zagreb, Croatia, 2001, 195-195

Skup
8th European Symposium on Organic Reactivity

Mjesto i datum
Cavtat, Hrvatska, 01.09.2001. - 06.09.2001

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
ferrocene aliphatic and aromatic diols; stereoselective acylation; optical purity; chiral columns

Sažetak
The aim of the work presented was a study of stereoselectivity in biocatalyzed acylation of some ferrocene diols depending on lenght of the containing aliphatic chain or aromatic ring substituted with hydroxy functions. With this intention a series of racemic ferrocene aliphatic (1-5) and aromatic diols (6-8) were prepared by reduction of the corresponding keto esters. Each of these diols contains one secondary and one primary carbinol group, separated by 1-5 methylene units or by benzene ring. The carbinols prepared underwent stereoselective acylation in benzene at 27 °C by the action of vinyl acetate as acyl group donor in the presence of various lipases giving the corresponding acetates (9-16). The course of these conversions was followed by the HPLC technique and the optical purity of the compounds prepared was examined on a chiral column Chiracel OD-H and Chiracel OJ.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

POVEZANOST RADA