Naslov
Can glycated albumin assist in management of diabetes mellitus?

Autori
Lenicek Krleza, Jasna

Izvornik
Biochemia medica : časopis hrvatskoga društva medicinskih biokemičara (1330-0962) 24 (2014), Supp. 1; 47-52

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Radovi u časopisima, pregledni rad, znanstveni

Ključne riječi
glycated albumin; diabetes mellitus

Sažetak
In some patients, levels of HbA1c are inadequate for determining the average glucose concentration and therefore for assessing glycemic state ; in such patients, this biomarker is useless for predicting diabetes complications likely to develop. Lack of linear correlation between HbA1c levels and average glucose concentration arises because numerous factors affect HbA1c levels, including genetics, hematological factors and the presence of certain comorbidities, such as hemoglobinopathy, certain anemias, and disorders associated with shorter erythrocyte lifespan. Diabetes management, especially in early phases, requires frequent monitoring because significant changes can occur within 2-3 months. Such monitoring is particularly important for individuals on therapy to treat prediabetes, patients undergoing new therapy or a change in their current therapy, individuals on intensive insulin therapy during early stages of diabetes, pregnant women and patients on hemodialysis. One candidate biomarker is albumin, which accounts for approximately 60% of serum proteins and is present in the blood at concentrations of 30-50 g/L. This protein is predicted to be highly susceptible to glycation because it contains numerous arginine and lysine residues near its N- and C-termini. In addition, it persists for 2-3 weeks once released into the circulation, making it potentially well-suited to be a biomarker that can detect short and mid-term changes. In order for glycated albumin to be measured routinely in the clinic, the American Diabetes Association in 2011 called for studies to develop a standardized method for its measurement as well as to clearly establish its clinical usefulness and reliability for predicting diabetes-related complications. Since then, numerous studies have tried to follow these recommendations and determine whether the level of glycated albumin can be useful in managing diabetes. Here we examine those efforts.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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