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Pregled bibliografske jedinice broj: 723959

Voltammetric study of the partitioning of macrolide antibiotics at the water/nitrobenzene interface. Relationship to the pharmacokinetic profiling of macrolides

Mandić, Zoran
Voltammetric study of the partitioning of macrolide antibiotics at the water/nitrobenzene interface. Relationship to the pharmacokinetic profiling of macrolides // ADMET and DMPK, 2 (2014), 3; 168-178 doi:10.5599/admet.2.3.46 (podatak o recenziji nije dostupan, članak, znanstveni)

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Naslov
Voltammetric study of the partitioning of macrolide antibiotics at the water/nitrobenzene interface. Relationship to the pharmacokinetic profiling of macrolides

Autori
Mandić, Zoran

Izvornik
ADMET and DMPK (1848-7718) 2 (2014), 3; 168-178

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
azithromycin ; erythromycin ; oleandomycin ; clarithromycin ; liquid/liquid interface ; cyclic voltammetry ; pharmacokinetics ; lipophilicity ; ADME

Sažetak
The ion transfer of a series of ionised 14- and 15- membered macrolide compounds across polarised water/nitrobenzene have been studied by cyclic voltammetry. Fourteen-membered macrolides transfer as singly-charged molecules in the wide pH range, while 15-membered macrolides can transfer as both singly and doubly protonated cations, depending on the pH of the aqueous solution. The results showed that the formal transfer potentials of the investigated compounds varied to a great extent and that minor changes in macrolide structure caused significant change in the corresponding formal transfer potentials. Among the investigated macrolides, azithromycin had the lowest formal transfer potential and its peculiar ADME behaviour is ascribed to this specific property.

Izvorni jezik
Engleski

Znanstvena područja
Kemijsko inženjerstvo



POVEZANOST RADA

Projekti:
MZOS-125-1252973-2576 - Temeljna i primijenjena istraživanja vodljivih polimera (Mandić, Zoran, MZOS ) ( CroRIS)

Ustanove:
Fakultet kemijskog inženjerstva i tehnologije, Zagreb

Profili:

Avatar Url Zoran Mandić (autor)

Poveznice na cjeloviti tekst rada:

doi doi.org hrcak.srce.hr pub.iapchem.org

Citiraj ovu publikaciju:

Mandić, Zoran
Voltammetric study of the partitioning of macrolide antibiotics at the water/nitrobenzene interface. Relationship to the pharmacokinetic profiling of macrolides // ADMET and DMPK, 2 (2014), 3; 168-178 doi:10.5599/admet.2.3.46 (podatak o recenziji nije dostupan, članak, znanstveni)
Mandić, Z. (2014) Voltammetric study of the partitioning of macrolide antibiotics at the water/nitrobenzene interface. Relationship to the pharmacokinetic profiling of macrolides. ADMET and DMPK, 2 (3), 168-178 doi:10.5599/admet.2.3.46.
@article{article, author = {Mandi\'{c}, Zoran}, year = {2014}, pages = {168-178}, DOI = {10.5599/admet.2.3.46}, keywords = {azithromycin, erythromycin, oleandomycin, clarithromycin, liquid/liquid interface, cyclic voltammetry, pharmacokinetics, lipophilicity, ADME}, journal = {ADMET and DMPK}, doi = {10.5599/admet.2.3.46}, volume = {2}, number = {3}, issn = {1848-7718}, title = {Voltammetric study of the partitioning of macrolide antibiotics at the water/nitrobenzene interface. Relationship to the pharmacokinetic profiling of macrolides}, keyword = {azithromycin, erythromycin, oleandomycin, clarithromycin, liquid/liquid interface, cyclic voltammetry, pharmacokinetics, lipophilicity, ADME} }
@article{article, author = {Mandi\'{c}, Zoran}, year = {2014}, pages = {168-178}, DOI = {10.5599/admet.2.3.46}, keywords = {azithromycin, erythromycin, oleandomycin, clarithromycin, liquid/liquid interface, cyclic voltammetry, pharmacokinetics, lipophilicity, ADME}, journal = {ADMET and DMPK}, doi = {10.5599/admet.2.3.46}, volume = {2}, number = {3}, issn = {1848-7718}, title = {Voltammetric study of the partitioning of macrolide antibiotics at the water/nitrobenzene interface. Relationship to the pharmacokinetic profiling of macrolides}, keyword = {azithromycin, erythromycin, oleandomycin, clarithromycin, liquid/liquid interface, cyclic voltammetry, pharmacokinetics, lipophilicity, ADME} }

Časopis indeksira:


  • Web of Science Core Collection (WoSCC)
    • Emerging Sources Citation Index (ESCI)
  • Scopus

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