Naslov
DRUG USE IN PREGNANCY

Autori
Leppée, Marcel ; Čulig, Josip ; Polić-Vižintin M ; Grgić, Matijana.

Vrsta, podvrsta i kategorija rada
Radovi u zbornicima skupova, cjeloviti rad (in extenso), stručni

Skup
22 ND INTERNATIONAL CONFERENCE ON PHARMACOEPIDEMIOLOGY AND THERAPEUTIC RISK MANAGEMENT

Mjesto i datum
Lisabon, Portugal, 24.08.2006. - 27.08.2006

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
drug; pregnancy

Sažetak
INTRODUCTION The very high criteria for use of drugs in pregnant women preclude any clinical drug trial to complete in this population group. As pregnancy is characterized by high health susceptibility, the studies performed so far have been confined to the use of epidemiologic methods, also employed in this study. AIM To present the use of drugs in pregnancy and early postpartum period. Drugs were divided into four groups according to gestational age at the time of drug use: 1) drug introduced before and continued during pregnancy ; 2) drug introduced during pregnancy ; 3) drug used between hospital admission and delivery ; and 4) drug used during puerperium. METHODS As current ethical principles pose restrictions upon clinical therapeutic trials in pregnant women, epidemiologic methods were primarily employed in the study, i.e. a standardized structured questionnaire administered to a sample of pregnant women (N=893) exposed to various drugs before, during or after delivery. RESULTS The number of drugs used by women before and continued during pregnancy was rather low, as the study sample included young and healthy subjects. The leading group were cardiovascular drugs, used by 16 (n=1.8%) women, followed by antithyroid agents in 15 (n=1.7%), antidiabetics in 11 (n=1.2%), and others. The leading group during pregnancy and before hospital admission were vitamins, used by more than a half of study sample (n=523 ; 58.6%), followed by antibiotics and antimicrobials (n=461 ; 51.6%), antidepressants and anxiolytics (n=250 ; 28.0%), gynecologic agents (n=239 ; 26.8%), iron agents (n=220 ; 24.6%), antimycotics (n=145 ; 16.2%), cardiovascular agents (n=107 ; 12.0%), and others. The leading group of drugs taken between hospital admission and delivery were gynecologic agents (n=122 ; 13.7%), followed by analgesics (n=105 ; 11.8%), gastrointestinal agents (n=91 ; 10.2%), and antidepressants and anxiolytics (n=54 ; 6.1%). CONCLUSION Considering age structure and good health status of the study women, they reported a very low use of drugs before and at the beginning of pregnancy. The medication used was mostly related to chronic diseases (thyroid, diabetes, epilepsy). During pregnancy, women are especially caring and careful, tending to use as little drugs as possible, thus vitamins predominated in the reported medication, followed by antibiotics and antimicrobials, antidepressants and anxiolytics. Also, gynecologic and iron agents were taken in this period.

Izvorni jezik
Engleski

POVEZANOST RADA