Pregled bibliografske jedinice broj: 72244
Interorganellar communication: altered nuclear gene expression profiles in a yeast mitochondrial DNA mutant
Interorganellar communication: altered nuclear gene expression profiles in a yeast mitochondrial DNA mutant // EMBO Lecture Course : Cellular Signalling in development and disease : Abstracts / Terzić, J. ; Dikić, I. ; Čikeš, V. (ur.).
Split, 2001. str. 41-41 (predavanje, međunarodna recenzija, sažetak, stručni)
CROSBI ID: 72244 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Interorganellar communication: altered nuclear gene expression profiles in a yeast mitochondrial DNA mutant
Autori
Traven, Ana ; Wong, Johnson ; Xu, Deming ; Ingles, C. James ; Sopta, Mary
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, stručni
Izvornik
EMBO Lecture Course : Cellular Signalling in development and disease : Abstracts
/ Terzić, J. ; Dikić, I. ; Čikeš, V. - Split, 2001, 41-41
Skup
EMBO Lecture Course : Cellular Signalling in development and disease
Mjesto i datum
Split, Hrvatska, 21.09.2001. - 27.09.2001
Vrsta sudjelovanja
Predavanje
Vrsta recenzije
Međunarodna recenzija
Ključne riječi
yeast; mitochondria; microarray; multi-drug resistance
Sažetak
Communication between mitochondria and the nucleus is important for a variety of cellular processes such as carbohydrate and nitrogen metabolism, mating and sporulation and cell growth and morphogenesis. It has long been known that the functional state of mitochondria can influence nuclear gene expression> For example, in yeast cells lacking the mitochondrial genome, the expression of several nuclear genes, such as CIT2 (citrate synthase), MRP13 (mitochondrial ribosomal protein) and DLD3 (d-lactate dehydrogenase) has been reported to be altered. Here we show by microarray analysis of the genome-wide transcription profile of Saccharomyces cerevisiae that yeast petite mutants lacking mitochondrial DNA induce genes coding for mitochondrial proteins, enzymes of the glycolytic pathway and the citric acid cycle, cell wall components, membrane transporters and genes normally induced by nutrient deprivation and a variety of stresses. Consistent with the observed induction of genes related to stress and those encoding membrane transporters, yeast petite cells showed increased resistance to severe heat shock and exhibited a multidrug resistance phenotype. The observed changes in nuclear gene expression in cells lacking mitochondrial DNA may have implications for the role of mitochondria in processes such as carcinogenesis and aging.
Izvorni jezik
Engleski
Znanstvena područja
Biologija
