Pregled bibliografske jedinice broj: 720956
Colorectal cancer, novel biomarkers and immunohistochemistry, an overview
Colorectal cancer, novel biomarkers and immunohistochemistry, an overview // Rad Hrvatske akademije znanosti i umjetnosti. Medicinske znanosti, 520 (2014), 40; 41-49 (podatak o recenziji nije dostupan, članak, stručni)
CROSBI ID: 720956 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Colorectal cancer, novel biomarkers and immunohistochemistry, an overview
Autori
Ulamec, Monika ; Krušlin Božo
Izvornik
Rad Hrvatske akademije znanosti i umjetnosti. Medicinske znanosti (1330-5301) 520
(2014), 40;
41-49
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, stručni
Ključne riječi
colorectal cancer; biomarkers; microsatellite instability; KRAS; BRAF
Sažetak
Colorectal cancer (CRC) is the most common cancer in Europe and leading cause of death. A combination of therapy with targeted agents and also knowledge of many biomarkers is significantly increasing to better guide selection of treatment. Biomarkers which are currently used as predictive and prognostic as well as factors for therapy selection are described in this overview. It refers to microsatellite instability (MSI), RAS- family of oncogenes, BRAF, TP53, Ki-67, Oncotype DX_, phosphatidylinositol 3-kinase (PI3K)/AKT, 18q LOH and CpG island methylator phenotype. Only a few biomarkers are currently used and in routine reported by pathologist. Future studies need to consider the combination of markers, standardizing protocols and if possible simple and standardized assays for the detection of molecular markers.
Izvorni jezik
Engleski
Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti
POVEZANOST RADA
Projekti:
108-1081870-1884 - Razvojna neuropatologija genetskih malformacija moždane kore čovjeka (Krušlin, Božo, MZOS ) ( CroRIS)
Ustanove:
Medicinski fakultet, Zagreb,
KBC "Sestre Milosrdnice"
