Naslov
Nonalcoholic fatty liver disease (NAFLD) ; is it a new risk factor for adverse cardiovascular events in renal transplant recipients?

Autori
Mikolašević, Ivana ; Rački, Sanjin ; Zaputović, Luka ; Lukenda, Vesna ; Sladoje-Martinović, Branka ; Orlić, Lidija

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
7. hrvatski kongres nefrologije, dijalize i transplantacije s međunarodnim sudjelovanjem : knjiga sažetaka ; u: Acta medica Croatica 68 (2014) (S2) / Rački, Sanjin - Zagreb, 2014, 284-284

Skup
Hrvatski kongres nefrologije, dijalize i transplantacije s međunarodnim sudjelovanjem (7 ; 2014)

Mjesto i datum
Pula, Hrvatska, 10.10.2014. - 12.10.2014

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Domaća recenzija

Ključne riječi
transplantation; nonalcoholic fatty liver disease; cardiovascular risk

Sažetak
Renal transplant recipients (RTRs) have a high risk for cardiovascular (CVD) mortality. Recently, nonalcoholic fatty liver disease (NAFLD) has been recognized as a new risk factor for adverse CVD events in general population. We examined whether transient elastography (TE) defined NAFLD was associated with atherosclerosis in RTRs, as measured by ultrasound in the carotid arteries. Carotid atherosclerosis was assesses in 71 RTRs with a TE proven NAFLD. With the help of TE liver stiffness was used to assess liver fibrosis and Controlled Attenuation Parameter (CAP) was used to detect and quantify liver steatosis. NAFLD was defined by the presence of steatosis with CAP values ≥238 dB.m-1. RTRs with NAFLD showed more carotid atherosclerosis than RTRs without NAFLD. RTRs-NAFLD patients had the mean intima-media measurements (ITM) of 1.1±0.1 mm and that was statistically significant higher than the mean ITM founded in RTRs without NAFLD (1.1±0.1 vs. 0.9±0.1 mm ; p<0.0001). Furthermore, RTRs-NAFLD patients had statistically significant higher prevalence of plaques in comparison with RTRs without NAFLD (p=0.021). We showed for the first time that carotid atherosclerosis is advanced in RTRs with NAFLD. Detection of NAFLD by TE should alert to the existence of an increased cardiovascular risk in RTRs.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

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