Naslov
Synthesis of Some of New Biologycally Active (1) benzothieno (2,3-c)quinolin-6-ones

Autori
Dogan Koružnjak, Jasna ; Karminski-Zamola, Grace

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, ostalo

Izvornik
Book of Abstracts / Feringa - Groningen, 2001, P1-156

Skup
ESOC 12thEuropean Symposium on Organic Chemistry

Mjesto i datum
Groningen, Nizozemska, 13.07.2001. - 18.07.2001

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
heterocycles; benzothienoquinolones; biological activity; antitumor agents

Sažetak
Some new polycyclic heterocyclic compounds of the quinolone type shown on Figure 1 were prepared by multistep synthesis.1 Common feature of all the compounds synthesized is that they have at least one N-[3-(dimethylamino)propyl] group which is present in number of substances possessing antiviral activity.2 Figure 1. Structure of [1]benzothieno[2,3-c]quinolin-6-ones The reactions of photocyclization of anilides, acylation of amines with carboxylic chlorides and esters and N-alkylation of amides were used as a final step in the synthesis of corresponding quinolone derivatives. Prepared quinolones are tested on antitumor activity and showed very intensive action "in vitro" on some human carcinoma.3 Testing "in vivo" is in course.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

POVEZANOST RADA